Genome Scanning for Segments Shared Identical by Descent among Distant Relatives in Isolated Populations

In this paper, we address some of the statistical issues concerning false-positive rates that arise when the whole genome, or a portion thereof, is scanned in distantly related individuals, to search for a disease locus. We derive a method for correcting false-positive probabilities for the large nu...

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Veröffentlicht in:	American journal of human genetics 1997-10, Vol.61 (4), p.830-842
Hauptverfasser:	Durham, L. Kathryn, Feingold, Eleanor
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological and medical sciences Chromosomes, Human Classical genetics, quantitative genetics, hybrids Computerized, statistical medical data processing and models in biomedicine Consanguinity False Positive Reactions Family Female Fundamental and applied biological sciences. Psychology Genetic Diseases, Inborn - genetics Genetic Linkage Genetic Techniques Genetics of eukaryotes. Biological and molecular evolution Genome, Human Humans Male Medical sciences Medical statistics Methods, theories and miscellaneous Models, Genetic Pedigree Probability
Online-Zugang:	Volltext
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