A high proportion of novel mutations in BRCA1 with strong founder effects among Dutch and Belgian hereditary breast and ovarian cancer families

We have identified 79 mutations in BRCA1 in a set of 643 Dutch and 23 Belgian hereditary breast and ovarian cancer families collected either for research or for clinical diagnostic purposes. Twenty-eight distinct mutations have been observed, 18 of them not previously reported and 12 of them occurri...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of human genetics 1997-05, Vol.60 (5), p.1041-1049
Hauptverfasser:	PEELEN, T, VAN VLIET, M, VAN DER LUIJT, R, VAN DER HOUT, A. H, GILLE, J. J. P, PALS, G, JEDEMA, I, OLMER, R, VAN LEEUWEN, I, NEWMAN, B, PLANDSOEN, M, VAN DER EST, M, PETRIJ-BOSCH, A, BRINK, G, HAGEMAN, S, ARTS, P. J. W, BAKKER, M. M, WILLEMS, H. W, VAN DER LOOIJ, E, NEYNS, B, BONDUELLE, M, JANSEN, R, OOSDERWIJK, J. C, MIEREMET, R, SIJMONS, R, SMEETS, H. J. M, VAN ASPEREN, C. J, MEIJERS-HEIJBOER, H, KLIJN, J. G. M, DE GREVE, J, KING, M.-C, MENKO, F. H, BRUNNER, H. G, HALLEY, D, SZABO, C, VAN OMMEN, G.-J. B, VASEN, H. F. A, CORNELISSE, C. J, VAN'VEER, L. J, DE KNIJFF, P, BAKKER, E, DEVILEE, P, VAN DEN OUWELAND, A. M. W, HOGERVORST, F, BROHET, R, LIGTENBERG, M. J. L, TEUGELS, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Belgium - epidemiology Biological and medical sciences Breast Neoplasms - epidemiology Breast Neoplasms - genetics Female Female genital diseases Founder Effect Gene Frequency Genes, BRCA1 Genetic Testing Genotype Gynecology. Andrology. Obstetrics Haplotypes Humans Incidence Medical sciences Mutation Netherlands - epidemiology Original Ovarian Neoplasms - epidemiology Ovarian Neoplasms - genetics Phenotype Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!