The effects of time varying curvature on species transport in coronary arteries
Alterations in mass transport patterns of low-density lipoproteins (LDL) and oxygen are known to cause atherosclerosis in larger arteries. We hypothesise that the species transport processes in coronary arteries may be affected by their physiological motion, a factor which has not been considered wi...
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| Veröffentlicht in: | Annals of biomedical engineering 2006-12, Vol.34 (12), p.1820-1832 |
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| creator | Kolandavel, Maheshwaran K Fruend, Ernst-Torben Ringgaard, Steffen Walker, Peter G |
| description | Alterations in mass transport patterns of low-density lipoproteins (LDL) and oxygen are known to cause atherosclerosis in larger arteries. We hypothesise that the species transport processes in coronary arteries may be affected by their physiological motion, a factor which has not been considered widely in mass transfer studies. Hence, we numerically simulated the mass transport of LDL and oxygen in an idealized moving coronary artery model under both steady and pulsatile flow conditions. A physiological inlet velocity and a sinusoidal curvature waveform were specified as velocity and wall motion boundary conditions. The results predicted elevation of LDL flux, impaired oxygen flux and low wall shear stress (WSS) along the inner wall of curvature, a predilection site for atherosclerosis. The wall motion induced changes in the velocity and WSS patterns were only secondary to the pulsatile flow effects. The temporal variations in flow and WSS due to the flow pulsation and wall motion did not affect temporal changes in the species wall flux. However, the wall motion did alter the time-averaged oxygen and LDL flux in the order of 26% and 12% respectively. Taken together, these results suggest that the wall motion may play an important role in coronary arterial transport processes and emphasise the need for further investigation. |
| doi_str_mv | 10.1007/s10439-006-9188-3 |
| format | Article |
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We hypothesise that the species transport processes in coronary arteries may be affected by their physiological motion, a factor which has not been considered widely in mass transfer studies. Hence, we numerically simulated the mass transport of LDL and oxygen in an idealized moving coronary artery model under both steady and pulsatile flow conditions. A physiological inlet velocity and a sinusoidal curvature waveform were specified as velocity and wall motion boundary conditions. The results predicted elevation of LDL flux, impaired oxygen flux and low wall shear stress (WSS) along the inner wall of curvature, a predilection site for atherosclerosis. The wall motion induced changes in the velocity and WSS patterns were only secondary to the pulsatile flow effects. The temporal variations in flow and WSS due to the flow pulsation and wall motion did not affect temporal changes in the species wall flux. However, the wall motion did alter the time-averaged oxygen and LDL flux in the order of 26% and 12% respectively. Taken together, these results suggest that the wall motion may play an important role in coronary arterial transport processes and emphasise the need for further investigation.</description><identifier>ISSN: 0090-6964</identifier><identifier>EISSN: 1573-9686</identifier><identifier>EISSN: 1521-6047</identifier><identifier>DOI: 10.1007/s10439-006-9188-3</identifier><identifier>PMID: 17051428</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Atherosclerosis ; Biological Transport - physiology ; Boundary conditions ; Computer Simulation ; Coronary Artery Disease - metabolism ; Coronary Artery Disease - physiopathology ; Coronary Vessels - physiology ; Fluctuations ; Humans ; Lipoproteins, LDL - metabolism ; Mass transfer ; Mass transport ; Models, Cardiovascular ; Oxygen ; Oxygen - metabolism ; Physiology ; Pulsatile Flow - physiology ; Shear stress ; Transport processes ; Veins & arteries</subject><ispartof>Annals of biomedical engineering, 2006-12, Vol.34 (12), p.1820-1832</ispartof><rights>Biomedical Engineering Society 2006</rights><rights>Springer Science+Business Media, LLC 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-b83bf021bf683a1ef3089911900c6ac3995ec2ac2e8d8fc7e5b022f999914ab73</citedby><cites>FETCH-LOGICAL-c518t-b83bf021bf683a1ef3089911900c6ac3995ec2ac2e8d8fc7e5b022f999914ab73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17051428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kolandavel, Maheshwaran K</creatorcontrib><creatorcontrib>Fruend, Ernst-Torben</creatorcontrib><creatorcontrib>Ringgaard, Steffen</creatorcontrib><creatorcontrib>Walker, Peter G</creatorcontrib><title>The effects of time varying curvature on species transport in coronary arteries</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><description>Alterations in mass transport patterns of low-density lipoproteins (LDL) and oxygen are known to cause atherosclerosis in larger arteries. We hypothesise that the species transport processes in coronary arteries may be affected by their physiological motion, a factor which has not been considered widely in mass transfer studies. Hence, we numerically simulated the mass transport of LDL and oxygen in an idealized moving coronary artery model under both steady and pulsatile flow conditions. A physiological inlet velocity and a sinusoidal curvature waveform were specified as velocity and wall motion boundary conditions. The results predicted elevation of LDL flux, impaired oxygen flux and low wall shear stress (WSS) along the inner wall of curvature, a predilection site for atherosclerosis. The wall motion induced changes in the velocity and WSS patterns were only secondary to the pulsatile flow effects. The temporal variations in flow and WSS due to the flow pulsation and wall motion did not affect temporal changes in the species wall flux. However, the wall motion did alter the time-averaged oxygen and LDL flux in the order of 26% and 12% respectively. Taken together, these results suggest that the wall motion may play an important role in coronary arterial transport processes and emphasise the need for further investigation.</description><subject>Animals</subject><subject>Atherosclerosis</subject><subject>Biological Transport - physiology</subject><subject>Boundary conditions</subject><subject>Computer Simulation</subject><subject>Coronary Artery Disease - metabolism</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary Vessels - physiology</subject><subject>Fluctuations</subject><subject>Humans</subject><subject>Lipoproteins, LDL - metabolism</subject><subject>Mass transfer</subject><subject>Mass transport</subject><subject>Models, Cardiovascular</subject><subject>Oxygen</subject><subject>Oxygen - metabolism</subject><subject>Physiology</subject><subject>Pulsatile Flow - physiology</subject><subject>Shear stress</subject><subject>Transport processes</subject><subject>Veins & arteries</subject><issn>0090-6964</issn><issn>1573-9686</issn><issn>1521-6047</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkstqHDEQRUVIiCdOPiCbILKIV51USa3XJmBMXmDwxlkLtVyy28y0JlL3gP8-GmbIaxGrFlrUqUvV5TL2GuE9ApgPFaGXrgPQnUNrO_mErVAZ2Tlt9VO2AnDQaaf7E_ai1nsARCvVc3aCBhT2wq7Y1fUdcUqJ4lx5TnweN8R3oTyM0y2PS9mFeSnE88TrluJIlc8lTHWby8zHicdc8tRoHspMpbVfsmcprCu9Ov6n7PvnT9cXX7vLqy_fLs4vu6jQzt1g5ZBA4JC0lQEpSbDOITqAqEOUzimKIkRB9samaEgNIERy7WEfBiNP2ceD7nYZNnQTaWp7rf22jJu2js9h9H93pvHO3-ad35-uhG4CZ0eBkn8sVGe_GWuk9TpMlJfqrUQ0GkE18t1_SW1Ryb7VY6BA0aNRj4PolAZrZQPf_gPe56VMzVhvlDa9RmcbhAcollxrofTLBQS_z4k_5MS3nPh9Tvxe-M2f9v2eOAZD_gTIQbkE</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Kolandavel, Maheshwaran K</creator><creator>Fruend, Ernst-Torben</creator><creator>Ringgaard, Steffen</creator><creator>Walker, Peter G</creator><general>Springer Nature B.V</general><general>Kluwer Academic Publishers-Plenum Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7S</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20061201</creationdate><title>The effects of time varying curvature on species transport in coronary arteries</title><author>Kolandavel, Maheshwaran K ; Fruend, Ernst-Torben ; Ringgaard, Steffen ; Walker, Peter G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-b83bf021bf683a1ef3089911900c6ac3995ec2ac2e8d8fc7e5b022f999914ab73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Atherosclerosis</topic><topic>Biological Transport - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of biomedical engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kolandavel, Maheshwaran K</au><au>Fruend, Ernst-Torben</au><au>Ringgaard, Steffen</au><au>Walker, Peter G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of time varying curvature on species transport in coronary arteries</atitle><jtitle>Annals of biomedical engineering</jtitle><addtitle>Ann Biomed Eng</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>34</volume><issue>12</issue><spage>1820</spage><epage>1832</epage><pages>1820-1832</pages><issn>0090-6964</issn><eissn>1573-9686</eissn><eissn>1521-6047</eissn><abstract>Alterations in mass transport patterns of low-density lipoproteins (LDL) and oxygen are known to cause atherosclerosis in larger arteries. We hypothesise that the species transport processes in coronary arteries may be affected by their physiological motion, a factor which has not been considered widely in mass transfer studies. Hence, we numerically simulated the mass transport of LDL and oxygen in an idealized moving coronary artery model under both steady and pulsatile flow conditions. A physiological inlet velocity and a sinusoidal curvature waveform were specified as velocity and wall motion boundary conditions. The results predicted elevation of LDL flux, impaired oxygen flux and low wall shear stress (WSS) along the inner wall of curvature, a predilection site for atherosclerosis. The wall motion induced changes in the velocity and WSS patterns were only secondary to the pulsatile flow effects. The temporal variations in flow and WSS due to the flow pulsation and wall motion did not affect temporal changes in the species wall flux. However, the wall motion did alter the time-averaged oxygen and LDL flux in the order of 26% and 12% respectively. Taken together, these results suggest that the wall motion may play an important role in coronary arterial transport processes and emphasise the need for further investigation.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>17051428</pmid><doi>10.1007/s10439-006-9188-3</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of biomedical engineering, 2006-12, Vol.34 (12), p.1820-1832 |
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| subjects | Animals Atherosclerosis Biological Transport - physiology Boundary conditions Computer Simulation Coronary Artery Disease - metabolism Coronary Artery Disease - physiopathology Coronary Vessels - physiology Fluctuations Humans Lipoproteins, LDL - metabolism Mass transfer Mass transport Models, Cardiovascular Oxygen Oxygen - metabolism Physiology Pulsatile Flow - physiology Shear stress Transport processes Veins & arteries |
| title | The effects of time varying curvature on species transport in coronary arteries |
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