Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks

Topoisomerase II is a ubiquitous enzyme that removes knots and tangles from the genetic material by generating transient double‐strand DNA breaks. While the enzyme cannot perform its essential cellular functions without cleaving DNA, this scission activity is inherently dangerous to chromosomal inte...

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Veröffentlicht in:	Nucleic acids research 2003-08, Vol.31 (15), p.4373-4384
Hauptverfasser:	Sabourin, M, Nitiss, J.L, Nitiss, K.C, Tatebayashi, K, Ikeda, H, Osheroff, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Cell Division - drug effects DNA breakage DNA Damage DNA Repair DNA topoisomerase DNA Topoisomerases, Type II - metabolism double-stranded DNA breaks enzyme activity Etoposide - toxicity homologous recombination Models, Genetic Recombination, Genetic Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development yeasts
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