Intercellular Adhesion Molecule-1 Is Required for the Early Formation of Granulomas and Participates in the Resistance of Mice to the Infection with the Fungus Paracoccidioides brasiliensis

The migration of leukocytes to inflammatory sites elicited by Paracoccidioides brasiliensis is supposed to be coordinated by cytokines and chemokines. Here, we investigated the role of intercellular adhesion molecule-1 (ICAM-1) in recruiting inflammatory cells to lungs of mice infected with P. brasi...

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Veröffentlicht in:	The American journal of pathology 2006-10, Vol.169 (4), p.1270-1281
Hauptverfasser:	Moreira, Ana P., Campanelli, Ana P., Cavassani, Karen A., Souto, Janeusa T., Ferreira, Beatriz R., Martinez, Roberto, Rossi, Marcos A., Silva, João S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - analysis Biological and medical sciences Chemotaxis, Leukocyte - genetics Disease Susceptibility Granuloma - genetics Granuloma - immunology Granuloma - microbiology Intercellular Adhesion Molecule-1 - analysis Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - physiology Interferon-gamma - metabolism Interleukin-12 - metabolism Investigative techniques, diagnostic techniques (general aspects) Lung - chemistry Lung - immunology Lung - microbiology Male Medical sciences Mice Mice, Mutant Strains Paracoccidioides Paracoccidioides brasiliensis Paracoccidioidomycosis - genetics Paracoccidioidomycosis - immunology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Regular T-Lymphocytes - immunology Tumor Necrosis Factor-alpha - metabolism
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