Nell-1-Induced Bone Regeneration in Calvarial Defects

Many craniofacial birth defects contain skeletal components requiring bone grafting. We previously identified the novel secreted osteogenic molecule NELL-1, first noted to be overexpressed during premature bone formation in calvarial sutures of craniosynostosis patients. Nell-1 overexpression signif...

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Veröffentlicht in:	The American journal of pathology 2006-09, Vol.169 (3), p.903-915
Hauptverfasser:	Aghaloo, Tara, Cowan, Catherine M., Chou, Yu-Fen, Zhang, Xinli, Lee, Haofu, Miao, Steve, Hong, Nichole, Kuroda, Shun'ichi, Wu, Benjamin, Ting, Kang, Soo, Chia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Biomarkers - metabolism Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins - biosynthesis Bone Regeneration - genetics Calcinosis - genetics Calcinosis - metabolism Calcinosis - pathology Calcium-Binding Proteins Craniosynostoses - genetics Craniosynostoses - metabolism Craniosynostoses - pathology Glycoproteins Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Mice Mice, Transgenic Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Osteoblasts - metabolism Osteoblasts - pathology Osteocalcin - biosynthesis Osteogenesis - genetics Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Rats Receptor, Fibroblast Growth Factor, Type 2 - biosynthesis Regular Skull - abnormalities Skull - metabolism Skull - pathology Tissue Culture Techniques Transforming Growth Factor beta - biosynthesis Up-Regulation - genetics
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