Kinetic Analysis of Amyloid Protofibril Dissociation and Volumetric Properties of the Transition State

We present here the first detailed kinetic analysis of the dissociation reaction of amyloid protofibrils by utilizing pressure as an accelerator of the reaction. The experiment is carried out on an excessively diluted typical protofibril solution formed from an intrinsically denatured disulfide-defi...

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Veröffentlicht in:Biophysical journal 2007-01, Vol.92 (1), p.323-329
Hauptverfasser: Abdul Latif, Abdul Raziq, Kono, Ryohei, Tachibana, Hideki, Akasaka, Kazuyuki
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Sprache:eng
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