An Endothelium-Derived Hyperpolarizing Factor Distinct from NO and Prostacyclin Is a Major Endothelium-Dependent Vasodilator in Resistance Vessels of Wild-Type and Endothelial NO Synthase Knockout Mice

In addition to nitric oxide (NO) and prostacyclin (PGI2), the endothelium generates the endothelium-derived hyperpolarizing factor (EDHF). We set out to determine whether an EDHF-like response can be detected in wild-type (WT) and endothelial NO synthase knockout mice (eNOS -/-) mice. Vasodilator re...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-08, Vol.97 (17), p.9747-9752
Hauptverfasser:	Brandes, Ralf P., Schmitz-Winnenthal, Friedrich-Hubertus, Feletou, Michel, Godecke, Axel, Huang, Paul L., Vanhoutte, Paul M., Fleming, Ingrid, Busse, Rudi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Agonists Animals Arteries Arteries - drug effects Arteries - physiology Biological Factors - metabolism Biological Sciences Blood Pressure - drug effects Boluses Bradykinin - pharmacology Cholinergic receptors Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Diclofenac - pharmacology Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - metabolism Epoprostenol - metabolism Flow velocity Gap junctions Gap Junctions - drug effects Gap Junctions - physiology Gene Deletion Hindlimb - blood supply Hindlimb - drug effects In Vitro Techniques Mice Mice, Inbred C57BL Mice, Knockout NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - deficiency Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitroarginine - pharmacology Nitroprusside - pharmacology Perfusion Potassium Channel Blockers Potassium Channels - metabolism Receptors, Cannabinoid Receptors, Drug - antagonists & inhibitors Receptors, Drug - metabolism Vasodilation Vasodilation - drug effects Vasodilator Agents - metabolism Vasodilator Agents - pharmacology Vasodilators
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