Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer
It is well established that cancers affect differentiation of dendritic cells and promote systemic expansion of immune suppressive immature myeloid cells. This phenomenon may represent a mechanism of tumor escape from immune attack and could have significant impact on tumor progression. In this revi...
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| Veröffentlicht in: | Cancer and metastasis reviews 2006-09, Vol.25 (3), p.323-331 |
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| container_title | Cancer and metastasis reviews |
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| creator | Kusmartsev, Sergei Gabrilovich, Dmitry I |
| description | It is well established that cancers affect differentiation of dendritic cells and promote systemic expansion of immune suppressive immature myeloid cells. This phenomenon may represent a mechanism of tumor escape from immune attack and could have significant impact on tumor progression. In this review we discuss the role of different tumor-derived factors, which were implicated in abnormal myeloid cell differentiation. The role of reactive oxygen species as well as JAK/STAT signaling in mechanisms of the effects of tumor-derived factors on myeloid cells is also discussed. |
| doi_str_mv | 10.1007/s10555-006-9002-6 |
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| ispartof | Cancer and metastasis reviews, 2006-09, Vol.25 (3), p.323-331 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Cell Differentiation Cytokines - metabolism Humans Janus Kinases - physiology Macrophages - immunology Mice Myeloid Cells - cytology Myeloid Cells - immunology Neoplasms - immunology STAT Transcription Factors - physiology Tumor Escape |
| title | Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer |
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