Transmission dynamics of a zoonotic pathogen within and between wildlife host species
The transmission dynamics of the cowpox virus infection have been quantified in two mixed populations of bank voles (Clethrionomys glareolus) and wood mice (Apodemus sylvaticus), through analyses of detailed time-series of the numbers of susceptible, infectious and newly infected individuals. The co...
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| Veröffentlicht in: | Proceedings of the Royal Society. B, Biological sciences Biological sciences, 1999-10, Vol.266 (1432), p.1939-1945 |
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| container_issue | 1432 |
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| container_title | Proceedings of the Royal Society. B, Biological sciences |
| container_volume | 266 |
| creator | Begon, M Hazel, S.M Baxby, D Bown, K Cavanagh, R Chantrey, J Jones, T Bennett, M |
| description | The transmission dynamics of the cowpox virus infection have been quantified in two mixed populations of bank voles (Clethrionomys glareolus) and wood mice (Apodemus sylvaticus), through analyses of detailed time-series of the numbers of susceptible, infectious and newly infected individuals. The cowpox virus is a zoonosis which circulates in these rodent hosts and has been shown to have an adverse effect on reproductive output. The transmission dynamics within species is best described as frequency dependent rather than density dependent, contrary to the 'mass action' assumption of most previous studies, both theoretical and empirical. Estimation of a transmission coefficient for each species in each population also allows annual and seasonal variations in transmission dynamics to be investigated through an analysis of regression residuals. Transmission between host species is found to be negligible despite their close co-habitation. The consequences of this for the combining ability of hosts as zoonotic reservoirs, and for apparent competition between hosts, are discussed. |
| doi_str_mv | 10.1098/rspb.1999.0870 |
| format | Article |
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The cowpox virus is a zoonosis which circulates in these rodent hosts and has been shown to have an adverse effect on reproductive output. The transmission dynamics within species is best described as frequency dependent rather than density dependent, contrary to the 'mass action' assumption of most previous studies, both theoretical and empirical. Estimation of a transmission coefficient for each species in each population also allows annual and seasonal variations in transmission dynamics to be investigated through an analysis of regression residuals. Transmission between host species is found to be negligible despite their close co-habitation. The consequences of this for the combining ability of hosts as zoonotic reservoirs, and for apparent competition between hosts, are discussed.</description><identifier>ISSN: 0962-8452</identifier><identifier>EISSN: 1471-2954</identifier><identifier>DOI: 10.1098/rspb.1999.0870</identifier><identifier>PMID: 10584336</identifier><language>eng</language><publisher>England: The Royal Society</publisher><subject>Animals ; Apodemus ; Apodemus sylvaticus ; Apparent Competition ; Arvicolinae ; Clethnonomys ; Clethrionomys glareolus ; Cowpox ; Cowpox - immunology ; Cowpox - transmission ; Cowpox - veterinary ; Cowpox - virology ; Cowpox virus ; Cowpox virus - immunology ; Cowpox virus - isolation & purification ; Disease transmission ; Host-Pathogen Dynamics ; infection ; Infections ; Linear Models ; Mice ; Models, Biological ; Muridae ; Pathogens ; Population dynamics ; Population ecology ; Sexual transmission ; Transmission Dynamics ; Viruses ; Voles ; wildlife ; Zoonoses</subject><ispartof>Proceedings of the Royal Society. B, Biological sciences, 1999-10, Vol.266 (1432), p.1939-1945</ispartof><rights>Copyright 1999 The Royal Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c642t-11e3bd4bae8d6d4e303b07d6e842aedbf879870527c76a15731d5e8e079794883</citedby><cites>FETCH-LOGICAL-c642t-11e3bd4bae8d6d4e303b07d6e842aedbf879870527c76a15731d5e8e079794883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/51584$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/51584$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10584336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Begon, M</creatorcontrib><creatorcontrib>Hazel, S.M</creatorcontrib><creatorcontrib>Baxby, D</creatorcontrib><creatorcontrib>Bown, K</creatorcontrib><creatorcontrib>Cavanagh, R</creatorcontrib><creatorcontrib>Chantrey, J</creatorcontrib><creatorcontrib>Jones, T</creatorcontrib><creatorcontrib>Bennett, M</creatorcontrib><title>Transmission dynamics of a zoonotic pathogen within and between wildlife host species</title><title>Proceedings of the Royal Society. B, Biological sciences</title><addtitle>Proc Biol Sci</addtitle><description>The transmission dynamics of the cowpox virus infection have been quantified in two mixed populations of bank voles (Clethrionomys glareolus) and wood mice (Apodemus sylvaticus), through analyses of detailed time-series of the numbers of susceptible, infectious and newly infected individuals. The cowpox virus is a zoonosis which circulates in these rodent hosts and has been shown to have an adverse effect on reproductive output. The transmission dynamics within species is best described as frequency dependent rather than density dependent, contrary to the 'mass action' assumption of most previous studies, both theoretical and empirical. Estimation of a transmission coefficient for each species in each population also allows annual and seasonal variations in transmission dynamics to be investigated through an analysis of regression residuals. Transmission between host species is found to be negligible despite their close co-habitation. The consequences of this for the combining ability of hosts as zoonotic reservoirs, and for apparent competition between hosts, are discussed.</description><subject>Animals</subject><subject>Apodemus</subject><subject>Apodemus sylvaticus</subject><subject>Apparent Competition</subject><subject>Arvicolinae</subject><subject>Clethnonomys</subject><subject>Clethrionomys glareolus</subject><subject>Cowpox</subject><subject>Cowpox - immunology</subject><subject>Cowpox - transmission</subject><subject>Cowpox - veterinary</subject><subject>Cowpox - virology</subject><subject>Cowpox virus</subject><subject>Cowpox virus - immunology</subject><subject>Cowpox virus - isolation & purification</subject><subject>Disease transmission</subject><subject>Host-Pathogen Dynamics</subject><subject>infection</subject><subject>Infections</subject><subject>Linear Models</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Muridae</subject><subject>Pathogens</subject><subject>Population dynamics</subject><subject>Population ecology</subject><subject>Sexual transmission</subject><subject>Transmission Dynamics</subject><subject>Viruses</subject><subject>Voles</subject><subject>wildlife</subject><subject>Zoonoses</subject><issn>0962-8452</issn><issn>1471-2954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAYhCMEYkvhyoED5MQtxY6_LwhYUUBaCSG2XC0ncRqX1A62Swm_HmezqrYH4GTF78yT1zNZ9hSCFQSCv_JhqFZQCLECnIF72QJiBotSEHw_WwBBy4JjUl5kj0LYAQAE4eRhdgEB4Rghusg2117ZsDchGGfzZrRqb-qQuzZX-W_nrIumzgcVO7fVNj-a2BmbK9vklY5HfXPVN71pdd65EPMw6Nro8Dh70Ko-6Ce35zLbrN9fX34srj5_-HT59qqoKS5jAaFGVYMrpXlDG6wRQBVgDdUcl0o3VcuZSK8iJasZVZAwBBuiuQZMMIE5R8vs9cwdDtVeN7W20ateDt7slR-lU0aeT6zp5Nb9lJAKgCBKgJe3AO9-HHSIMkVR675XVrtDkFQglAJl_xVChpOOgCRczcLauxC8bk_bQCCnyuRUmZwqk1NlyfD87hvuyOeOkgDNAu_GFKZLAcdR7tzB2_T5d-yz2bUL0fkTlcCJusyKeWhC1L9OQ-W_S8oQI_Ibx3KN-DtGvqzlBHsz6zuz7Y7Ga3m2y82va2djSlmWlEqIUZl2QUK2hz710bQJUf4T4cbBh-rcnUwvZlOrnFRbb4LcfC0BRKAUCBAI0B-fzO_R</recordid><startdate>19991007</startdate><enddate>19991007</enddate><creator>Begon, M</creator><creator>Hazel, S.M</creator><creator>Baxby, D</creator><creator>Bown, K</creator><creator>Cavanagh, R</creator><creator>Chantrey, J</creator><creator>Jones, T</creator><creator>Bennett, M</creator><general>The Royal Society</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SN</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19991007</creationdate><title>Transmission dynamics of a zoonotic pathogen within and between wildlife host species</title><author>Begon, M ; Hazel, S.M ; Baxby, D ; Bown, K ; Cavanagh, R ; Chantrey, J ; Jones, T ; Bennett, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c642t-11e3bd4bae8d6d4e303b07d6e842aedbf879870527c76a15731d5e8e079794883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Apodemus</topic><topic>Apodemus sylvaticus</topic><topic>Apparent Competition</topic><topic>Arvicolinae</topic><topic>Clethnonomys</topic><topic>Clethrionomys glareolus</topic><topic>Cowpox</topic><topic>Cowpox - immunology</topic><topic>Cowpox - transmission</topic><topic>Cowpox - veterinary</topic><topic>Cowpox - virology</topic><topic>Cowpox virus</topic><topic>Cowpox virus - immunology</topic><topic>Cowpox virus - isolation & purification</topic><topic>Disease transmission</topic><topic>Host-Pathogen Dynamics</topic><topic>infection</topic><topic>Infections</topic><topic>Linear Models</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Muridae</topic><topic>Pathogens</topic><topic>Population dynamics</topic><topic>Population ecology</topic><topic>Sexual transmission</topic><topic>Transmission Dynamics</topic><topic>Viruses</topic><topic>Voles</topic><topic>wildlife</topic><topic>Zoonoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Begon, M</creatorcontrib><creatorcontrib>Hazel, S.M</creatorcontrib><creatorcontrib>Baxby, D</creatorcontrib><creatorcontrib>Bown, K</creatorcontrib><creatorcontrib>Cavanagh, R</creatorcontrib><creatorcontrib>Chantrey, J</creatorcontrib><creatorcontrib>Jones, T</creatorcontrib><creatorcontrib>Bennett, M</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Ecology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the Royal Society. B, Biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Begon, M</au><au>Hazel, S.M</au><au>Baxby, D</au><au>Bown, K</au><au>Cavanagh, R</au><au>Chantrey, J</au><au>Jones, T</au><au>Bennett, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmission dynamics of a zoonotic pathogen within and between wildlife host species</atitle><jtitle>Proceedings of the Royal Society. B, Biological sciences</jtitle><addtitle>Proc Biol Sci</addtitle><date>1999-10-07</date><risdate>1999</risdate><volume>266</volume><issue>1432</issue><spage>1939</spage><epage>1945</epage><pages>1939-1945</pages><issn>0962-8452</issn><eissn>1471-2954</eissn><abstract>The transmission dynamics of the cowpox virus infection have been quantified in two mixed populations of bank voles (Clethrionomys glareolus) and wood mice (Apodemus sylvaticus), through analyses of detailed time-series of the numbers of susceptible, infectious and newly infected individuals. The cowpox virus is a zoonosis which circulates in these rodent hosts and has been shown to have an adverse effect on reproductive output. The transmission dynamics within species is best described as frequency dependent rather than density dependent, contrary to the 'mass action' assumption of most previous studies, both theoretical and empirical. Estimation of a transmission coefficient for each species in each population also allows annual and seasonal variations in transmission dynamics to be investigated through an analysis of regression residuals. Transmission between host species is found to be negligible despite their close co-habitation. The consequences of this for the combining ability of hosts as zoonotic reservoirs, and for apparent competition between hosts, are discussed.</abstract><cop>England</cop><pub>The Royal Society</pub><pmid>10584336</pmid><doi>10.1098/rspb.1999.0870</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the Royal Society. B, Biological sciences, 1999-10, Vol.266 (1432), p.1939-1945 |
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| subjects | Animals Apodemus Apodemus sylvaticus Apparent Competition Arvicolinae Clethnonomys Clethrionomys glareolus Cowpox Cowpox - immunology Cowpox - transmission Cowpox - veterinary Cowpox - virology Cowpox virus Cowpox virus - immunology Cowpox virus - isolation & purification Disease transmission Host-Pathogen Dynamics infection Infections Linear Models Mice Models, Biological Muridae Pathogens Population dynamics Population ecology Sexual transmission Transmission Dynamics Viruses Voles wildlife Zoonoses |
| title | Transmission dynamics of a zoonotic pathogen within and between wildlife host species |
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