SWISS-MODEL: an automated protein homology-modeling server
SWISS-MODEL (http://swissmodel.expasy.org) is a server for automated comparative modeling of three-dimensional (3D) protein structures. It pioneered the field of automated modeling starting in 1993 and is the most widely-used free web-based automated modeling facility today. In 2002 the server compu...
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| Veröffentlicht in: | Nucleic acids research 2003-07, Vol.31 (13), p.3381-3385 |
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| creator | Schwede, Torsten Kopp, Jürgen Guex, Nicolas Peitsch, Manuel C. |
| description | SWISS-MODEL (http://swissmodel.expasy.org) is a server for automated comparative modeling of three-dimensional (3D) protein structures. It pioneered the field of automated modeling starting in 1993 and is the most widely-used free web-based automated modeling facility today. In 2002 the server computed 120 000 user requests for 3D protein models. SWISS-MODEL provides several levels of user interaction through its World Wide Web interface: in the ‘first approach mode’ only an amino acid sequence of a protein is submitted to build a 3D model. Template selection, alignment and model building are done completely automated by the server. In the ‘alignment mode’, the modeling process is based on a user-defined target-template alignment. Complex modeling tasks can be handled with the ‘project mode’ using DeepView (Swiss-PdbViewer), an integrated sequence-to-structure workbench. All models are sent back via email with a detailed modeling report. WhatCheck analyses and ANOLEA evaluations are provided optionally. The reliability of SWISS-MODEL is continuously evaluated in the EVA-CM project. The SWISS-MODEL server is under constant development to improve the successful implementation of expert knowledge into an easy-to-use server. |
| doi_str_mv | 10.1093/nar/gkg520 |
| format | Article |
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Acids Res</addtitle><description>SWISS-MODEL (http://swissmodel.expasy.org) is a server for automated comparative modeling of three-dimensional (3D) protein structures. It pioneered the field of automated modeling starting in 1993 and is the most widely-used free web-based automated modeling facility today. In 2002 the server computed 120 000 user requests for 3D protein models. SWISS-MODEL provides several levels of user interaction through its World Wide Web interface: in the ‘first approach mode’ only an amino acid sequence of a protein is submitted to build a 3D model. Template selection, alignment and model building are done completely automated by the server. In the ‘alignment mode’, the modeling process is based on a user-defined target-template alignment. Complex modeling tasks can be handled with the ‘project mode’ using DeepView (Swiss-PdbViewer), an integrated sequence-to-structure workbench. All models are sent back via email with a detailed modeling report. 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| fulltext | fulltext |
| identifier | ISSN: 0305-1048 |
| ispartof | Nucleic acids research, 2003-07, Vol.31 (13), p.3381-3385 |
| issn | 0305-1048 1362-4962 1362-4962 |
| language | eng |
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| source | MEDLINE; PubMed Central; Free Full-Text Journals in Chemistry; Oxford Academic Journals (Open Access) |
| subjects | Computer Graphics Internet Models, Molecular Proteins - chemistry Sequence Alignment Sequence Analysis, Protein Software Structural Homology, Protein User-Computer Interface |
| title | SWISS-MODEL: an automated protein homology-modeling server |
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