On the slowly rising phase of the sodium gating current in the squid giant axon
High-resolution records of the sodium gating current in the squid giant axon demonstrate the existence of a slowly rising phase that is first apparent at pulse potentials slightly below zero, and becomes increasingly pronounced at more positive potentials. At +80 mV the current reaches its peak with...
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| Veröffentlicht in: | Proceedings of the Royal Society. B, Biological sciences Biological sciences, 1998-02, Vol.265 (1393), p.255-262 |
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| creator | Keynes, R.D. Elinder, F. |
| description | High-resolution records of the sodium gating current in the squid giant axon demonstrate the existence of a slowly rising phase that is first apparent at pulse potentials slightly below zero, and becomes increasingly pronounced at more positive potentials. At +80 mV the current reaches its peak with a delay of 30 μs at 10°C. It is suggested that this current is generated by the first two steps labelled R ←P and P ←A in the S4 units of all four domains of the series-parallel gating system, activating the channel before its opening by the third steps A ←B in domains I, II and III in conjunction with hydration. The kinetics of the slowly rising phase can only be explained by the incorporation of an appropriate degree of voltage-dependent cooperativity between the S4 voltage-sensors for their two initial transitions. |
| doi_str_mv | 10.1098/rspb.1998.0290 |
| format | Article |
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B, Biological sciences</title><addtitle>Proc Biol Sci</addtitle><description>High-resolution records of the sodium gating current in the squid giant axon demonstrate the existence of a slowly rising phase that is first apparent at pulse potentials slightly below zero, and becomes increasingly pronounced at more positive potentials. At +80 mV the current reaches its peak with a delay of 30 μs at 10°C. It is suggested that this current is generated by the first two steps labelled R ←P and P ←A in the S4 units of all four domains of the series-parallel gating system, activating the channel before its opening by the third steps A ←B in domains I, II and III in conjunction with hydration. The kinetics of the slowly rising phase can only be explained by the incorporation of an appropriate degree of voltage-dependent cooperativity between the S4 voltage-sensors for their two initial transitions.</description><subject>Animals</subject><subject>Axons</subject><subject>Axons - physiology</subject><subject>Cephalopoda</subject><subject>Data files</subject><subject>Decapodiformes</subject><subject>Electric current</subject><subject>Electric potential</subject><subject>Experimental data</subject><subject>Ion Channel Gating</subject><subject>Ion Transport</subject><subject>Kinetics</subject><subject>Loligo forbesi</subject><subject>Marine</subject><subject>Medicin och hälsovetenskap</subject><subject>Membrane Potentials</subject><subject>Neurons - physiology</subject><subject>Sodium</subject><subject>Sodium channels</subject><subject>Sodium Channels - physiology</subject><subject>Sodium Gating Current</subject><subject>Squid</subject><subject>Squid Axon</subject><subject>TECHNOLOGY</subject><subject>TEKNIKVETENSKAP</subject><subject>Time constants</subject><issn>0962-8452</issn><issn>1471-2954</issn><issn>1471-2954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqFks1v0zAYxiMEGmNw5YCElBMnUvyZ2BfQOmBDmijiY9dXTuKk7tK4s5N15a_HaaqKCm1EimL7-b1f8RNFLzGaYCTFO-dX-QRLKSaISPQoOsYswwmRnD2OjpFMSSIYJ0-jZ94vEEKSC34UHUlOKCPZcTSbtXE317Fv7LrZxM5409bxaq68jm01SrY0_TKuVTdIRe-cbrvY7OJuelPGtVHhSN3Z9nn0pFKN1y9235Po1-dPP88uksvZ-Zez08ukEEh2CSlQISUhgua04giVqmIloljxElVYaoYESzFCBFdVkessx4yIgmas5FynmNCTSIx5_Vqv-hxWziyV24BVJqxtCbvzazO84DUM_0ViOYS-vTf0o7k6BetqaEwPXGacB_z9iAd2qcsiDO9Uc1jwQGnNHGp7CzgV4UlDgje7BM7e9Np3sDS-0E2jWm17D1koQzHN_gvilBNGGA7gZAQLZ713utp3gxEMroDBFTC4AgZXhIDXf8-wx3c2CDoddWc34dZsYXS3gYXtXRu292f1D0V9__FtGmB0S1JuMJUUkKAYZYRRCb_NaptuACAAYLzvwyUN2GGZf6u-GqsufGfdfhSOBJFBTEbR-E7f7UXlriHNaMbhSjCgGZ5eTM-_wsDjkZ-ber42TsPBLGGzcj7fNrhtjWwN8eHBmKHdwrZdsMNBIFR9E3xTVvQPwTUrsw</recordid><startdate>19980222</startdate><enddate>19980222</enddate><creator>Keynes, R.D.</creator><creator>Elinder, F.</creator><general>The Royal Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TN</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DG8</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>19980222</creationdate><title>On the slowly rising phase of the sodium gating current in the squid giant axon</title><author>Keynes, R.D. ; Elinder, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c809t-2c0c992283b3f500daf4d031a5d0f19e4084610021ffcbe7b1428c374d55e6123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Axons</topic><topic>Axons - physiology</topic><topic>Cephalopoda</topic><topic>Data files</topic><topic>Decapodiformes</topic><topic>Electric current</topic><topic>Electric potential</topic><topic>Experimental data</topic><topic>Ion Channel Gating</topic><topic>Ion Transport</topic><topic>Kinetics</topic><topic>Loligo forbesi</topic><topic>Marine</topic><topic>Medicin och hälsovetenskap</topic><topic>Membrane Potentials</topic><topic>Neurons - physiology</topic><topic>Sodium</topic><topic>Sodium channels</topic><topic>Sodium Channels - physiology</topic><topic>Sodium Gating Current</topic><topic>Squid</topic><topic>Squid Axon</topic><topic>TECHNOLOGY</topic><topic>TEKNIKVETENSKAP</topic><topic>Time constants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keynes, R.D.</creatorcontrib><creatorcontrib>Elinder, F.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Oceanic Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Linköpings universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Proceedings of the Royal Society. 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At +80 mV the current reaches its peak with a delay of 30 μs at 10°C. It is suggested that this current is generated by the first two steps labelled R ←P and P ←A in the S4 units of all four domains of the series-parallel gating system, activating the channel before its opening by the third steps A ←B in domains I, II and III in conjunction with hydration. The kinetics of the slowly rising phase can only be explained by the incorporation of an appropriate degree of voltage-dependent cooperativity between the S4 voltage-sensors for their two initial transitions.</abstract><cop>England</cop><pub>The Royal Society</pub><pmid>9523427</pmid><doi>10.1098/rspb.1998.0290</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0962-8452 |
| ispartof | Proceedings of the Royal Society. B, Biological sciences, 1998-02, Vol.265 (1393), p.255-262 |
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| subjects | Animals Axons Axons - physiology Cephalopoda Data files Decapodiformes Electric current Electric potential Experimental data Ion Channel Gating Ion Transport Kinetics Loligo forbesi Marine Medicin och hälsovetenskap Membrane Potentials Neurons - physiology Sodium Sodium channels Sodium Channels - physiology Sodium Gating Current Squid Squid Axon TECHNOLOGY TEKNIKVETENSKAP Time constants |
| title | On the slowly rising phase of the sodium gating current in the squid giant axon |
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