model for restriction fragment length distributions
We develop here a model for restriction fragment length distributions based on DNA dimer frequencies in humans. Mean fragment lengths are computed for known restriction enzymes. This model is tested using data from the hybridization of a series of arbitrary single-copy DNA probes screened with a set...
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| Veröffentlicht in: | American journal of human genetics 1983-01, Vol.35 (5), p.795-815 |
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| container_end_page | 815 |
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| container_title | American journal of human genetics |
| container_volume | 35 |
| creator | Bishop, D.T Williamson, J.A Skolnick, M.H |
| description | We develop here a model for restriction fragment length distributions based on DNA dimer frequencies in humans. Mean fragment lengths are computed for known restriction enzymes. This model is tested using data from the hybridization of a series of arbitrary single-copy DNA probes screened with a set of restriction enzymes. The fit to the model appears good. We apply the model to the problem of how much DNA is scanned by a set of enzymes. This result is then further applied to optimizing the search for insertion/deletion DNA-polymorphisms. |
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Mean fragment lengths are computed for known restriction enzymes. This model is tested using data from the hybridization of a series of arbitrary single-copy DNA probes screened with a set of restriction enzymes. The fit to the model appears good. We apply the model to the problem of how much DNA is scanned by a set of enzymes. This result is then further applied to optimizing the search for insertion/deletion DNA-polymorphisms.</description><identifier>ISSN: 0002-9297</identifier><identifier>EISSN: 1537-6605</identifier><identifier>PMID: 6310992</identifier><identifier>CODEN: AJHGAG</identifier><language>eng</language><publisher>Chicago, IL: University of Chicago Press</publisher><subject>Base Sequence ; Biological and medical sciences ; deoxyribonuclease I ; DNA ; dna fragments ; DNA probes ; DNA Restriction Enzymes ; DNA Transposable Elements ; equations ; Fundamental and applied biological sciences. Psychology ; Genes. Genome ; Humans ; mathematical models ; matrices ; Models, Genetic ; Molecular and cellular biology ; Molecular genetics ; Nucleic Acid Hybridization ; nucleotide sequences ; Polymorphism, Genetic ; restriction enzymes ; restriction mapping ; transition matrix</subject><ispartof>American journal of human genetics, 1983-01, Vol.35 (5), p.795-815</ispartof><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1685811/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1685811/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9618029$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6310992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bishop, D.T</creatorcontrib><creatorcontrib>Williamson, J.A</creatorcontrib><creatorcontrib>Skolnick, M.H</creatorcontrib><title>model for restriction fragment length distributions</title><title>American journal of human genetics</title><addtitle>Am J Hum Genet</addtitle><description>We develop here a model for restriction fragment length distributions based on DNA dimer frequencies in humans. Mean fragment lengths are computed for known restriction enzymes. This model is tested using data from the hybridization of a series of arbitrary single-copy DNA probes screened with a set of restriction enzymes. The fit to the model appears good. We apply the model to the problem of how much DNA is scanned by a set of enzymes. This result is then further applied to optimizing the search for insertion/deletion DNA-polymorphisms.</description><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>deoxyribonuclease I</subject><subject>DNA</subject><subject>dna fragments</subject><subject>DNA probes</subject><subject>DNA Restriction Enzymes</subject><subject>DNA Transposable Elements</subject><subject>equations</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes. Genome</subject><subject>Humans</subject><subject>mathematical models</subject><subject>matrices</subject><subject>Models, Genetic</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Nucleic Acid Hybridization</subject><subject>nucleotide sequences</subject><subject>Polymorphism, Genetic</subject><subject>restriction enzymes</subject><subject>restriction mapping</subject><subject>transition matrix</subject><issn>0002-9297</issn><issn>1537-6605</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9LwzAYhoMoc07_BLEH8Vb4kjRpchFk-AsGHnTnkqZpF2mbmbSC_72ZK0NPnnJ4Ht7vzXuE5pjRPOUc2DGaAwBJJZH5KToL4R0AYwF0hmacYpCSzBHtXGXapHY-8SYM3urBuj6pvWo60w9Ja_pm2CSV3bFy3MFwjk5q1QZzMb0LtH64f1s-pauXx-fl3SqtacaGtFJ1LSWWBDThTCsiCc8AEypLYrgpNcmU0QLKkptcV5wIDlKInFFtBOGGLtDtPnc7lp2pdOzjVVtsve2U_yqcssVf0ttN0bjPAnPBBMYx4GYK8O5jjN8rOhu0aVvVGzeGQgDPGCPyXxFTSSGTEMXL35UOXaY9I7-euApatXHGXttw0CSP-__cu9prtXKFanxU1q8EMAWcMxzXo99Hwoju</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Bishop, D.T</creator><creator>Williamson, J.A</creator><creator>Skolnick, M.H</creator><general>University of Chicago Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19830101</creationdate><title>model for restriction fragment length distributions</title><author>Bishop, D.T ; Williamson, J.A ; Skolnick, M.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f345t-daff991920c265ca2926401239b2e6ebc24aec80bb6e7cd62860988753ce826e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>deoxyribonuclease I</topic><topic>DNA</topic><topic>dna fragments</topic><topic>DNA probes</topic><topic>DNA Restriction Enzymes</topic><topic>DNA Transposable Elements</topic><topic>equations</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes. Genome</topic><topic>Humans</topic><topic>mathematical models</topic><topic>matrices</topic><topic>Models, Genetic</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Nucleic Acid Hybridization</topic><topic>nucleotide sequences</topic><topic>Polymorphism, Genetic</topic><topic>restriction enzymes</topic><topic>restriction mapping</topic><topic>transition matrix</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bishop, D.T</creatorcontrib><creatorcontrib>Williamson, J.A</creatorcontrib><creatorcontrib>Skolnick, M.H</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bishop, D.T</au><au>Williamson, J.A</au><au>Skolnick, M.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>model for restriction fragment length distributions</atitle><jtitle>American journal of human genetics</jtitle><addtitle>Am J Hum Genet</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>35</volume><issue>5</issue><spage>795</spage><epage>815</epage><pages>795-815</pages><issn>0002-9297</issn><eissn>1537-6605</eissn><coden>AJHGAG</coden><abstract>We develop here a model for restriction fragment length distributions based on DNA dimer frequencies in humans. Mean fragment lengths are computed for known restriction enzymes. This model is tested using data from the hybridization of a series of arbitrary single-copy DNA probes screened with a set of restriction enzymes. The fit to the model appears good. We apply the model to the problem of how much DNA is scanned by a set of enzymes. This result is then further applied to optimizing the search for insertion/deletion DNA-polymorphisms.</abstract><cop>Chicago, IL</cop><pub>University of Chicago Press</pub><pmid>6310992</pmid><tpages>21</tpages></addata></record> |
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| ispartof | American journal of human genetics, 1983-01, Vol.35 (5), p.795-815 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Base Sequence Biological and medical sciences deoxyribonuclease I DNA dna fragments DNA probes DNA Restriction Enzymes DNA Transposable Elements equations Fundamental and applied biological sciences. Psychology Genes. Genome Humans mathematical models matrices Models, Genetic Molecular and cellular biology Molecular genetics Nucleic Acid Hybridization nucleotide sequences Polymorphism, Genetic restriction enzymes restriction mapping transition matrix |
| title | model for restriction fragment length distributions |
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