Interethnic genetic differentiation in Africa : HLA class I antigens in the Gambia
A total of 752 individuals from The Gambia, west Africa who are representative of the major ethnic groups in the capital, Banjul, were serologically typed for HLA-A, -B, and -C antigens. Although all were typically "African" in their antigenic profiles, some marked frequency differences we...
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| Veröffentlicht in: | American journal of human genetics 1992-02, Vol.50 (2), p.411-421 |
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| creator | ALLSOPP, C. E. M HARDING, R. M TAYLOR, C BUNCE, M KWIATKOWSKI, D ANSTEY, N BREWSTER, D MCMICHAEL, A. J GREENWOOD, B. M HILL, A. V. S |
| description | A total of 752 individuals from The Gambia, west Africa who are representative of the major ethnic groups in the capital, Banjul, were serologically typed for HLA-A, -B, and -C antigens. Although all were typically "African" in their antigenic profiles, some marked frequency differences were found between the ethnic groups. Genetic distance comparisons with several other African populations showed that, although these west African populations clustered closely together, the positions of the various ethnic groups in The Gambia were consistent with historical and linguistic evidence of their affinities with one another and with other African populations. Despite the potential confounding effects both of selection by infectious diseases and of genetic drift caused by local differences in population structure, HLA frequencies appear to be of value in measuring inter- and intraregional population affinities in sub-Saharan Africa. |
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E. M ; HARDING, R. M ; TAYLOR, C ; BUNCE, M ; KWIATKOWSKI, D ; ANSTEY, N ; BREWSTER, D ; MCMICHAEL, A. J ; GREENWOOD, B. M ; HILL, A. V. S</creator><creatorcontrib>ALLSOPP, C. E. M ; HARDING, R. M ; TAYLOR, C ; BUNCE, M ; KWIATKOWSKI, D ; ANSTEY, N ; BREWSTER, D ; MCMICHAEL, A. J ; GREENWOOD, B. M ; HILL, A. V. S</creatorcontrib><description>A total of 752 individuals from The Gambia, west Africa who are representative of the major ethnic groups in the capital, Banjul, were serologically typed for HLA-A, -B, and -C antigens. Although all were typically "African" in their antigenic profiles, some marked frequency differences were found between the ethnic groups. Genetic distance comparisons with several other African populations showed that, although these west African populations clustered closely together, the positions of the various ethnic groups in The Gambia were consistent with historical and linguistic evidence of their affinities with one another and with other African populations. Despite the potential confounding effects both of selection by infectious diseases and of genetic drift caused by local differences in population structure, HLA frequencies appear to be of value in measuring inter- and intraregional population affinities in sub-Saharan Africa.</description><identifier>ISSN: 0002-9297</identifier><identifier>EISSN: 1537-6605</identifier><identifier>PMID: 1734720</identifier><identifier>CODEN: AJHGAG</identifier><language>eng</language><publisher>Chicago, IL: University of Chicago Press</publisher><subject>Africa ; Alleles ; Biological and medical sciences ; Ethnic Groups - genetics ; Fundamental and applied biological sciences. Psychology ; Gambia ; Genes, MHC Class I ; Genetic Variation ; Genetics of eukaryotes. Biological and molecular evolution ; Genetics, Population ; histocompatibility antigen HLA-B ; histocompatibility antigen HLA-C ; Human ; Humans ; Population genetics, reproduction patterns</subject><ispartof>American journal of human genetics, 1992-02, Vol.50 (2), p.411-421</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1682463/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1682463/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5169157$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1734720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ALLSOPP, C. E. M</creatorcontrib><creatorcontrib>HARDING, R. M</creatorcontrib><creatorcontrib>TAYLOR, C</creatorcontrib><creatorcontrib>BUNCE, M</creatorcontrib><creatorcontrib>KWIATKOWSKI, D</creatorcontrib><creatorcontrib>ANSTEY, N</creatorcontrib><creatorcontrib>BREWSTER, D</creatorcontrib><creatorcontrib>MCMICHAEL, A. J</creatorcontrib><creatorcontrib>GREENWOOD, B. M</creatorcontrib><creatorcontrib>HILL, A. V. S</creatorcontrib><title>Interethnic genetic differentiation in Africa : HLA class I antigens in the Gambia</title><title>American journal of human genetics</title><addtitle>Am J Hum Genet</addtitle><description>A total of 752 individuals from The Gambia, west Africa who are representative of the major ethnic groups in the capital, Banjul, were serologically typed for HLA-A, -B, and -C antigens. Although all were typically "African" in their antigenic profiles, some marked frequency differences were found between the ethnic groups. Genetic distance comparisons with several other African populations showed that, although these west African populations clustered closely together, the positions of the various ethnic groups in The Gambia were consistent with historical and linguistic evidence of their affinities with one another and with other African populations. Despite the potential confounding effects both of selection by infectious diseases and of genetic drift caused by local differences in population structure, HLA frequencies appear to be of value in measuring inter- and intraregional population affinities in sub-Saharan Africa.</description><subject>Africa</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Ethnic Groups - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gambia</subject><subject>Genes, MHC Class I</subject><subject>Genetic Variation</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genetics, Population</subject><subject>histocompatibility antigen HLA-B</subject><subject>histocompatibility antigen HLA-C</subject><subject>Human</subject><subject>Humans</subject><subject>Population genetics, reproduction patterns</subject><issn>0002-9297</issn><issn>1537-6605</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF9LwzAUxYMoc04_gpAH8a2QP03S-iCModtgIIg-l9s02SJtOptM8NsbsQx98unAPb97OJwTNKWCq0xKIk7RlBDCspKV6hxdhPBGCKUF4RM0oYrnipEpel77aAYTd95pvDXexKSNszYdfXQQXe-x83huB6cB3-HVZo51CyHgNYZEpJ_wDcSdwUvoageX6MxCG8zVqDP0-vjwslhlm6flejHfZHvOaMyMyUtleC1A5DwnSkvBG2VLaGqhLS04ZbkiJbGEctOIWgtlqRXUlqpuQOZ8hu5_cveHujONTn0HaKv94DoYPqseXPXX8W5XbfuPisqC5ZKngNsxYOjfDybEqnNBm7YFb_pDqBRTJWey-BekknIm0rIzdP270rHLOHfyb0YfgobWDuC1C0dMUFlSofgXdx-JZw</recordid><startdate>19920201</startdate><enddate>19920201</enddate><creator>ALLSOPP, C. E. M</creator><creator>HARDING, R. M</creator><creator>TAYLOR, C</creator><creator>BUNCE, M</creator><creator>KWIATKOWSKI, D</creator><creator>ANSTEY, N</creator><creator>BREWSTER, D</creator><creator>MCMICHAEL, A. J</creator><creator>GREENWOOD, B. M</creator><creator>HILL, A. V. S</creator><general>University of Chicago Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T3</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19920201</creationdate><title>Interethnic genetic differentiation in Africa : HLA class I antigens in the Gambia</title><author>ALLSOPP, C. E. M ; HARDING, R. M ; TAYLOR, C ; BUNCE, M ; KWIATKOWSKI, D ; ANSTEY, N ; BREWSTER, D ; MCMICHAEL, A. J ; GREENWOOD, B. M ; HILL, A. V. 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M</au><au>TAYLOR, C</au><au>BUNCE, M</au><au>KWIATKOWSKI, D</au><au>ANSTEY, N</au><au>BREWSTER, D</au><au>MCMICHAEL, A. J</au><au>GREENWOOD, B. M</au><au>HILL, A. V. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interethnic genetic differentiation in Africa : HLA class I antigens in the Gambia</atitle><jtitle>American journal of human genetics</jtitle><addtitle>Am J Hum Genet</addtitle><date>1992-02-01</date><risdate>1992</risdate><volume>50</volume><issue>2</issue><spage>411</spage><epage>421</epage><pages>411-421</pages><issn>0002-9297</issn><eissn>1537-6605</eissn><coden>AJHGAG</coden><abstract>A total of 752 individuals from The Gambia, west Africa who are representative of the major ethnic groups in the capital, Banjul, were serologically typed for HLA-A, -B, and -C antigens. Although all were typically "African" in their antigenic profiles, some marked frequency differences were found between the ethnic groups. 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| subjects | Africa Alleles Biological and medical sciences Ethnic Groups - genetics Fundamental and applied biological sciences. Psychology Gambia Genes, MHC Class I Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genetics, Population histocompatibility antigen HLA-B histocompatibility antigen HLA-C Human Humans Population genetics, reproduction patterns |
| title | Interethnic genetic differentiation in Africa : HLA class I antigens in the Gambia |
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