Two-locus models of disease : comparison of likelihood and nonparametric linkage methods

The power to detect linkage for likelihood and nonparametric (Haseman-Elston, affected-sib-pair, and affected-pedigree-member) methods is compared for the case of a common, dichotomous trait resulting from the segregation of two loci. Pedigree data for several two-locus epistatic and heterogeneity m...

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Veröffentlicht in:	American journal of human genetics 1993-10, Vol.53 (4), p.908-915
Hauptverfasser:	GOLDIN, L. R, WEEKS, D. E
Format:	Artikel
Sprache:	eng
Schlagworte:	990200 > Mathematics & Computers BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL MARKERS Chromosome Mapping comparison Computer Simulation DISEASES EQUATIONS Female GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE General aspects. Genetic counseling Genetic Diseases, Inborn - genetics Genetic Linkage GENETIC MAPPING Humans Likelihood Functions linkage Lod Score Male MAPPING MATHEMATICAL MODELS 550400 > Genetics Medical genetics Medical sciences methodology Models, Genetic Pedigree PREDICTION EQUATIONS statistical genetics STATISTICAL MODELS
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