A duplicated region is responsible for the poly(ADP-ribose) polymerase polymorphism, on chromosome 13, associated with a predisposition to cancer

The poly(ADP-ribose) polymerase (PADPRP) gene (13q33-qter) depicts a two-allele (A/B) polymorphism. In the noncancer population, the frequency of the B allele is higher among blacks than among whites. Since the incidence of multiple myeloma and prostate and lung cancer is higher in the U.S. black po...

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Veröffentlicht in:	American journal of human genetics 1993, Vol.52 (1), p.124-134
Hauptverfasser:	LYN, D, CHERNEY, B. W, LALANDE, M, BERENSON, J. R, LICHTENSTEIN, A, LUPOLD, S, BHATIA, K. G, SMULSON, M
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP African Continental Ancestry Group - genetics ALDEHYDES Alleles Amino Acid Sequence Base Sequence BASIC BIOLOGICAL SCIENCES Biological and medical sciences BODY CARBOHYDRATES carcinoma chromosome 13 CHROMOSOMES Chromosomes, Human, Pair 13 DIGESTIVE SYSTEM DISEASES DISTRIBUTION DNA DNA SEQUENCING DNA, Neoplasm ENZYMES GASTROINTESTINAL TRACT Gene Frequency General aspects GENES Genetic Predisposition to Disease GLANDS HUMAN CHROMOSOMES Humans INTESTINES LARGE INTESTINE Lung Neoplasms - genetics LUNGS Male MALE GENITALS man MAPPING Medical sciences Molecular Sequence Data MONOSACCHARIDES Multigene Family Multiple Myeloma - genetics NAD super(+) ADP-ribosyltransferase NEOPLASMS Neoplasms - genetics NUCLEIC ACIDS NUCLEOTIDES NUCLEOTIDYLTRANSFERASES OLIGONUCLEOTIDES ORGANIC COMPOUNDS ORGANS PENTOSES PHOSPHORUS-GROUP TRANSFERASES Poly(ADP-ribose) Polymerases - genetics POLYMERASES Polymorphism, Genetic PROSTATE Prostatic Neoplasms - genetics PROTEINS RESPIRATORY SYSTEM restriction fragment length polymorphism RFLPS RIBOSE SACCHARIDES Sequence Alignment STRUCTURAL CHEMICAL ANALYSIS TRANSFERASES 550400 > Genetics Tumors
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