CBL1, a Calcium Sensor That Differentially Regulates Salt, Drought, and Cold Responses in Arabidopsis
Although calcium is a critical component in the signal transduction pathways that lead to stress gene expression in higher plants, little is known about the molecular mechanism underlying calcium function. It is believed that cellular calcium changes are perceived by sensor molecules, including calc...
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| Veröffentlicht in: | The Plant cell 2003-08, Vol.15 (8), p.1833-1845 |
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| container_title | The Plant cell |
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| creator | Cheong, Yong Hwa Kim, Kyung-Nam Pandey, Girdhar K. Gupta, Rajeev Grant, John J. Luan, Sheng |
| description | Although calcium is a critical component in the signal transduction pathways that lead to stress gene expression in higher plants, little is known about the molecular mechanism underlying calcium function. It is believed that cellular calcium changes are perceived by sensor molecules, including calcium binding proteins. The calcineurin B-like (CBL) protein family represents a unique group of calcium sensors in plants. A member of the family, CBL1, is highly inducible by multiple stress signals, implicating CBL1 in stress response pathways. When the CBL1 protein level was increased in transgenic Arabidopsis plants, it altered the stress response pathways in these plants. Although drought-induced gene expression was enhanced, gene induction by cold was inhibited. In addition, CBL1-overexpressing plants showed enhanced tolerance to salt and drought but reduced tolerance to freezing. By contrast, cbl1 null mutant plants showed enhanced cold induction and reduced drought induction of stress genes. The mutant plants displayed less tolerance to salt and drought but enhanced tolerance to freezing. These studies suggest that CBL1 functions as a positive regulator of salt and drought responses and a negative regulator of cold response in plants. |
| doi_str_mv | 10.1105/tpc.012393 |
| format | Article |
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It is believed that cellular calcium changes are perceived by sensor molecules, including calcium binding proteins. The calcineurin B-like (CBL) protein family represents a unique group of calcium sensors in plants. A member of the family, CBL1, is highly inducible by multiple stress signals, implicating CBL1 in stress response pathways. When the CBL1 protein level was increased in transgenic Arabidopsis plants, it altered the stress response pathways in these plants. Although drought-induced gene expression was enhanced, gene induction by cold was inhibited. In addition, CBL1-overexpressing plants showed enhanced tolerance to salt and drought but reduced tolerance to freezing. By contrast, cbl1 null mutant plants showed enhanced cold induction and reduced drought induction of stress genes. The mutant plants displayed less tolerance to salt and drought but enhanced tolerance to freezing. These studies suggest that CBL1 functions as a positive regulator of salt and drought responses and a negative regulator of cold response in plants.</description><identifier>ISSN: 1040-4651</identifier><identifier>EISSN: 1532-298X</identifier><identifier>DOI: 10.1105/tpc.012393</identifier><identifier>PMID: 12897256</identifier><language>eng</language><publisher>England: American Society of Plant Biologists</publisher><subject>Arabidopsis - drug effects ; Arabidopsis - genetics ; Arabidopsis - metabolism ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Base Sequence ; Calcium ; Calcium Signaling - physiology ; Cold Temperature ; DNA, Plant - genetics ; Drought ; Freezing ; Gels ; Gene Expression ; Genes ; Genes, Plant ; Genetic Markers ; Messenger RNA ; Mutation ; Osmotic Pressure ; Plant cells ; Plants ; Plants, Genetically Modified ; Sensors ; Sodium Chloride - pharmacology ; Water - metabolism</subject><ispartof>The Plant cell, 2003-08, Vol.15 (8), p.1833-1845</ispartof><rights>Copyright 2003 American Society of Plant Biologists</rights><rights>Copyright © 2003, American Society of Plant Biologists 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-505ca471735cf870758fc0e98d6c960fda067e404e9324e12ff1cfd4b96f51d53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3872013$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3872013$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12897256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheong, Yong Hwa</creatorcontrib><creatorcontrib>Kim, Kyung-Nam</creatorcontrib><creatorcontrib>Pandey, Girdhar K.</creatorcontrib><creatorcontrib>Gupta, Rajeev</creatorcontrib><creatorcontrib>Grant, John J.</creatorcontrib><creatorcontrib>Luan, Sheng</creatorcontrib><title>CBL1, a Calcium Sensor That Differentially Regulates Salt, Drought, and Cold Responses in Arabidopsis</title><title>The Plant cell</title><addtitle>Plant Cell</addtitle><description>Although calcium is a critical component in the signal transduction pathways that lead to stress gene expression in higher plants, little is known about the molecular mechanism underlying calcium function. It is believed that cellular calcium changes are perceived by sensor molecules, including calcium binding proteins. The calcineurin B-like (CBL) protein family represents a unique group of calcium sensors in plants. A member of the family, CBL1, is highly inducible by multiple stress signals, implicating CBL1 in stress response pathways. When the CBL1 protein level was increased in transgenic Arabidopsis plants, it altered the stress response pathways in these plants. Although drought-induced gene expression was enhanced, gene induction by cold was inhibited. In addition, CBL1-overexpressing plants showed enhanced tolerance to salt and drought but reduced tolerance to freezing. By contrast, cbl1 null mutant plants showed enhanced cold induction and reduced drought induction of stress genes. The mutant plants displayed less tolerance to salt and drought but enhanced tolerance to freezing. These studies suggest that CBL1 functions as a positive regulator of salt and drought responses and a negative regulator of cold response in plants.</description><subject>Arabidopsis - drug effects</subject><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - metabolism</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Base Sequence</subject><subject>Calcium</subject><subject>Calcium Signaling - physiology</subject><subject>Cold Temperature</subject><subject>DNA, Plant - genetics</subject><subject>Drought</subject><subject>Freezing</subject><subject>Gels</subject><subject>Gene Expression</subject><subject>Genes</subject><subject>Genes, Plant</subject><subject>Genetic Markers</subject><subject>Messenger RNA</subject><subject>Mutation</subject><subject>Osmotic Pressure</subject><subject>Plant cells</subject><subject>Plants</subject><subject>Plants, Genetically Modified</subject><subject>Sensors</subject><subject>Sodium Chloride - pharmacology</subject><subject>Water - metabolism</subject><issn>1040-4651</issn><issn>1532-298X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVoyVdz6bkUnXoIcTpjWbZ86CFxmrawUGhSyE1oZWlXQWs5kh3Iv6_CLkl76lw0MM-MXngIeY9wjgj88zTqc8CStWyPHCJnZVG24u5N7qGCoqo5HpCjlO4BABts98kBlqJtSl4fEtNdLvCMKtopr928oTdmSCHS27Wa6JWz1kQzTE55_0R_mdXs1WQSvVF-OqNXMcyrdW7U0NMu-D4TaQxDyoQb6EVUS9eHMbn0jry1yidzsnuPye_rr7fd92Lx89uP7mJR6IqLqeDAtaoabBjXVjTQcGE1mFb0tW5rsL2CujEVVKZlZWWwtBa17atlW1uOPWfH5Mv27jgvN6bXOXpUXo7RbVR8kkE5-e9kcGu5Co8S6-df8_6n3X4MD7NJk9y4pI33ajBhTjIHY5jrvyAKIbIPyODpFtQxpBSNfQmDIJ_tyWxPbu1l-OPf8V_Rna4MfNgC92kK8WXORFMCMvYHS7WfLw</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Cheong, Yong Hwa</creator><creator>Kim, Kyung-Nam</creator><creator>Pandey, Girdhar K.</creator><creator>Gupta, Rajeev</creator><creator>Grant, John J.</creator><creator>Luan, Sheng</creator><general>American Society of Plant Biologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20030801</creationdate><title>CBL1, a Calcium Sensor That Differentially Regulates Salt, Drought, and Cold Responses in Arabidopsis</title><author>Cheong, Yong Hwa ; Kim, Kyung-Nam ; Pandey, Girdhar K. ; Gupta, Rajeev ; Grant, John J. ; Luan, Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-505ca471735cf870758fc0e98d6c960fda067e404e9324e12ff1cfd4b96f51d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Arabidopsis - drug effects</topic><topic>Arabidopsis - genetics</topic><topic>Arabidopsis - metabolism</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Base Sequence</topic><topic>Calcium</topic><topic>Calcium Signaling - physiology</topic><topic>Cold Temperature</topic><topic>DNA, Plant - genetics</topic><topic>Drought</topic><topic>Freezing</topic><topic>Gels</topic><topic>Gene Expression</topic><topic>Genes</topic><topic>Genes, Plant</topic><topic>Genetic Markers</topic><topic>Messenger RNA</topic><topic>Mutation</topic><topic>Osmotic Pressure</topic><topic>Plant cells</topic><topic>Plants</topic><topic>Plants, Genetically Modified</topic><topic>Sensors</topic><topic>Sodium Chloride - pharmacology</topic><topic>Water - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheong, Yong Hwa</creatorcontrib><creatorcontrib>Kim, Kyung-Nam</creatorcontrib><creatorcontrib>Pandey, Girdhar K.</creatorcontrib><creatorcontrib>Gupta, Rajeev</creatorcontrib><creatorcontrib>Grant, John J.</creatorcontrib><creatorcontrib>Luan, Sheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Plant cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheong, Yong Hwa</au><au>Kim, Kyung-Nam</au><au>Pandey, Girdhar K.</au><au>Gupta, Rajeev</au><au>Grant, John J.</au><au>Luan, Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CBL1, a Calcium Sensor That Differentially Regulates Salt, Drought, and Cold Responses in Arabidopsis</atitle><jtitle>The Plant cell</jtitle><addtitle>Plant Cell</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>15</volume><issue>8</issue><spage>1833</spage><epage>1845</epage><pages>1833-1845</pages><issn>1040-4651</issn><eissn>1532-298X</eissn><abstract>Although calcium is a critical component in the signal transduction pathways that lead to stress gene expression in higher plants, little is known about the molecular mechanism underlying calcium function. It is believed that cellular calcium changes are perceived by sensor molecules, including calcium binding proteins. The calcineurin B-like (CBL) protein family represents a unique group of calcium sensors in plants. A member of the family, CBL1, is highly inducible by multiple stress signals, implicating CBL1 in stress response pathways. When the CBL1 protein level was increased in transgenic Arabidopsis plants, it altered the stress response pathways in these plants. Although drought-induced gene expression was enhanced, gene induction by cold was inhibited. In addition, CBL1-overexpressing plants showed enhanced tolerance to salt and drought but reduced tolerance to freezing. By contrast, cbl1 null mutant plants showed enhanced cold induction and reduced drought induction of stress genes. The mutant plants displayed less tolerance to salt and drought but enhanced tolerance to freezing. These studies suggest that CBL1 functions as a positive regulator of salt and drought responses and a negative regulator of cold response in plants.</abstract><cop>England</cop><pub>American Society of Plant Biologists</pub><pmid>12897256</pmid><doi>10.1105/tpc.012393</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Arabidopsis - drug effects Arabidopsis - genetics Arabidopsis - metabolism Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Base Sequence Calcium Calcium Signaling - physiology Cold Temperature DNA, Plant - genetics Drought Freezing Gels Gene Expression Genes Genes, Plant Genetic Markers Messenger RNA Mutation Osmotic Pressure Plant cells Plants Plants, Genetically Modified Sensors Sodium Chloride - pharmacology Water - metabolism |
| title | CBL1, a Calcium Sensor That Differentially Regulates Salt, Drought, and Cold Responses in Arabidopsis |
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