THE POSTNATAL DEVELOPMENT OF ADRENOCEPTOR RESPONSES TO AGONISTS AND ELECTRICAL STIMULATION IN RAT ISOLATED ATRIA
1 Isolated right and left atria from rats of ages ranging from newborn to adult were used to measure chronotropic and inotropic responses to noradrenaline, isoprenaline, tyramine, and electrical stimulation of intramural nerves. 2 Right atria from newborn animals showed increases in rate with noradr...
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| Veröffentlicht in: | British journal of pharmacology 1978-09, Vol.64 (1), p.83-89 |
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| creator | STANDEN, N.B. |
| description | 1
Isolated right and left atria from rats of ages ranging from newborn to adult were used to measure chronotropic and inotropic responses to noradrenaline, isoprenaline, tyramine, and electrical stimulation of intramural nerves.
2
Right atria from newborn animals showed increases in rate with noradrenaline, isoprenaline, and tyramine which did not differ significantly from those of atria from adults. The ED50 values for the chronotropic actions of noradrenaline and isoprenaline were not significantly different at any age from the values in adult preparations.
3
Paced left atria from newborn rats showed well developed positive inotropic responses to noradrenaline and isoprenaline. Newborn left atria (and those from 1 and 2 week old animals) were supersensitive to noradrenaline but not to isoprenaline.
4
Left atria from newborn animals showed very small inotropic responses to both tyramine and field stimulation of intramural nerves. These responses developed progressively with age over the first three weeks of life. The results are discussed with respect to the development of cardiac β‐adrenoceptors and of cardiac sympathetic innervation. |
| doi_str_mv | 10.1111/j.1476-5381.1978.tb08644.x |
| format | Article |
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Isolated right and left atria from rats of ages ranging from newborn to adult were used to measure chronotropic and inotropic responses to noradrenaline, isoprenaline, tyramine, and electrical stimulation of intramural nerves.
2
Right atria from newborn animals showed increases in rate with noradrenaline, isoprenaline, and tyramine which did not differ significantly from those of atria from adults. The ED50 values for the chronotropic actions of noradrenaline and isoprenaline were not significantly different at any age from the values in adult preparations.
3
Paced left atria from newborn rats showed well developed positive inotropic responses to noradrenaline and isoprenaline. Newborn left atria (and those from 1 and 2 week old animals) were supersensitive to noradrenaline but not to isoprenaline.
4
Left atria from newborn animals showed very small inotropic responses to both tyramine and field stimulation of intramural nerves. These responses developed progressively with age over the first three weeks of life. The results are discussed with respect to the development of cardiac β‐adrenoceptors and of cardiac sympathetic innervation.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1978.tb08644.x</identifier><identifier>PMID: 698484</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aging ; Animals ; Electric Stimulation ; Female ; Heart - growth & development ; Heart - innervation ; Heart Rate - drug effects ; In Vitro Techniques ; Isoproterenol - pharmacology ; Male ; Myocardial Contraction - drug effects ; Rats ; Receptors, Adrenergic - drug effects ; Receptors, Adrenergic - physiology</subject><ispartof>British journal of pharmacology, 1978-09, Vol.64 (1), p.83-89</ispartof><rights>1978 British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4764-5cdbe093a2318db8f911e6ba185e693e5510f6213275d74643e36ee7dcc00ad03</citedby><cites>FETCH-LOGICAL-c4764-5cdbe093a2318db8f911e6ba185e693e5510f6213275d74643e36ee7dcc00ad03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1668259/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1668259/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/698484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STANDEN, N.B.</creatorcontrib><title>THE POSTNATAL DEVELOPMENT OF ADRENOCEPTOR RESPONSES TO AGONISTS AND ELECTRICAL STIMULATION IN RAT ISOLATED ATRIA</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
Isolated right and left atria from rats of ages ranging from newborn to adult were used to measure chronotropic and inotropic responses to noradrenaline, isoprenaline, tyramine, and electrical stimulation of intramural nerves.
2
Right atria from newborn animals showed increases in rate with noradrenaline, isoprenaline, and tyramine which did not differ significantly from those of atria from adults. The ED50 values for the chronotropic actions of noradrenaline and isoprenaline were not significantly different at any age from the values in adult preparations.
3
Paced left atria from newborn rats showed well developed positive inotropic responses to noradrenaline and isoprenaline. Newborn left atria (and those from 1 and 2 week old animals) were supersensitive to noradrenaline but not to isoprenaline.
4
Left atria from newborn animals showed very small inotropic responses to both tyramine and field stimulation of intramural nerves. These responses developed progressively with age over the first three weeks of life. The results are discussed with respect to the development of cardiac β‐adrenoceptors and of cardiac sympathetic innervation.</description><subject>Aging</subject><subject>Animals</subject><subject>Electric Stimulation</subject><subject>Female</subject><subject>Heart - growth & development</subject><subject>Heart - innervation</subject><subject>Heart Rate - drug effects</subject><subject>In Vitro Techniques</subject><subject>Isoproterenol - pharmacology</subject><subject>Male</subject><subject>Myocardial Contraction - drug effects</subject><subject>Rats</subject><subject>Receptors, Adrenergic - drug effects</subject><subject>Receptors, Adrenergic - physiology</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkUuP0zAUhS3Eqwz8AxYWC3YJdu04DgtGpvVMI2XiKPGwtfJwIVXalKRlZv79OGpVwRJvbPmce-6RPgA-YeRjd75sfExD5gWEYx9HIfcPFeKMUv_xBZhdpJdghhAKPYw5fwvejeMGISeGwRvwmkWccjoDe72SMFOFToUWCVzKHzJR2Z1MNVQ3UCxzmaqFzLTKYS6LTKWFLKBWUNyqNC50AUW6hDKRC53HCxdQ6PjuPhE6VimMU5gLDeNCuQ-5hMJ5xHvwal12o_1wvq_A_Y3Ui5WXqNspwatdfeoFdVNZFJFyTjBvKr6OMLasKjEPLIuIDQKM1myOyTwMmpAySixh1oZNXSNUNohcgW-n3P2x2tqmtrvDUHZmP7Tbcngyfdmaf5Vd-8v87P8YzBifB5EL-HwOGPrfRzsezLYda9t15c72x9GEFLPQtXPGrydjPfTjONj1ZQlGZsJlNmZiYiYmZsJlzrjMoxv--HfNy-iJj5OvT_JD29mn_wg237PV9CLPsGydYA</recordid><startdate>197809</startdate><enddate>197809</enddate><creator>STANDEN, N.B.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>197809</creationdate><title>THE POSTNATAL DEVELOPMENT OF ADRENOCEPTOR RESPONSES TO AGONISTS AND ELECTRICAL STIMULATION IN RAT ISOLATED ATRIA</title><author>STANDEN, N.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4764-5cdbe093a2318db8f911e6ba185e693e5510f6213275d74643e36ee7dcc00ad03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Electric Stimulation</topic><topic>Female</topic><topic>Heart - growth & development</topic><topic>Heart - innervation</topic><topic>Heart Rate - drug effects</topic><topic>In Vitro Techniques</topic><topic>Isoproterenol - pharmacology</topic><topic>Male</topic><topic>Myocardial Contraction - drug effects</topic><topic>Rats</topic><topic>Receptors, Adrenergic - drug effects</topic><topic>Receptors, Adrenergic - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STANDEN, N.B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STANDEN, N.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THE POSTNATAL DEVELOPMENT OF ADRENOCEPTOR RESPONSES TO AGONISTS AND ELECTRICAL STIMULATION IN RAT ISOLATED ATRIA</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1978-09</date><risdate>1978</risdate><volume>64</volume><issue>1</issue><spage>83</spage><epage>89</epage><pages>83-89</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>1
Isolated right and left atria from rats of ages ranging from newborn to adult were used to measure chronotropic and inotropic responses to noradrenaline, isoprenaline, tyramine, and electrical stimulation of intramural nerves.
2
Right atria from newborn animals showed increases in rate with noradrenaline, isoprenaline, and tyramine which did not differ significantly from those of atria from adults. The ED50 values for the chronotropic actions of noradrenaline and isoprenaline were not significantly different at any age from the values in adult preparations.
3
Paced left atria from newborn rats showed well developed positive inotropic responses to noradrenaline and isoprenaline. Newborn left atria (and those from 1 and 2 week old animals) were supersensitive to noradrenaline but not to isoprenaline.
4
Left atria from newborn animals showed very small inotropic responses to both tyramine and field stimulation of intramural nerves. These responses developed progressively with age over the first three weeks of life. The results are discussed with respect to the development of cardiac β‐adrenoceptors and of cardiac sympathetic innervation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>698484</pmid><doi>10.1111/j.1476-5381.1978.tb08644.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0007-1188 |
| ispartof | British journal of pharmacology, 1978-09, Vol.64 (1), p.83-89 |
| issn | 0007-1188 1476-5381 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1668259 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Aging Animals Electric Stimulation Female Heart - growth & development Heart - innervation Heart Rate - drug effects In Vitro Techniques Isoproterenol - pharmacology Male Myocardial Contraction - drug effects Rats Receptors, Adrenergic - drug effects Receptors, Adrenergic - physiology |
| title | THE POSTNATAL DEVELOPMENT OF ADRENOCEPTOR RESPONSES TO AGONISTS AND ELECTRICAL STIMULATION IN RAT ISOLATED ATRIA |
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