THE DISTRIBUTION AND METABOLISM OF ARACHIDONIC ACID IN RABBIT PLATELETS DURING AGGREGATION AND ITS MODIFICATION BY DRUGS

1Gas chromatographic and radio‐isotope labelling techniques have been used to establish the origin of the arachidonic acid used by the platelet cyclo‐oxygenase for the synthesis of pro‐aggregatory prostaglandin endoperoxide derivatives. 2Measurements of total platelet arachidonate content indicated...

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Veröffentlicht in:	British journal of pharmacology 1977-02, Vol.59 (2), p.353-366
Hauptverfasser:	BLACKWELL, G.J., DUNCOMBE, W.G., FLOWER, R.J., PARSONS, M.F., VANE, J.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acids - blood Blood Platelets - analysis Blood Platelets - drug effects Blood Platelets - enzymology Blood Platelets - metabolism Carbon Radioisotopes Chemical Phenomena Chemistry Chromatography, Gas Collagen - pharmacology Fatty Acids - blood Hydrolysis In Vitro Techniques Indomethacin - pharmacology Lipids - blood Male Phosphatidylcholines - metabolism Phospholipases - blood Phospholipids - blood Phosphorus - blood Platelet Aggregation - drug effects Quinacrine - pharmacology Rabbits Thrombin - pharmacology
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