Catecholamine concentrations and the activity of tyrosine hydroxylase after an increase in the concentration of tyrosine in rat tissues
The concentrations of tyrosine in rat plasma and brain were increased 2-7 fold by the administration of either L-tyrosine or cycloheximide. Under these conditions catecholamine concentrations in the brain and the heart remained unchanged even when the rats were maintained in a cold environment to in...
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| Veröffentlicht in: | British journal of pharmacology 1972-02, Vol.44 (2), p.307-310 |
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| container_title | British journal of pharmacology |
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| creator | Dairman, W. |
| description | The concentrations of tyrosine in rat plasma and brain were increased 2-7 fold by the administration of either L-tyrosine or cycloheximide. Under these conditions catecholamine concentrations in the brain and the heart remained unchanged even when the rats were maintained in a cold environment to increase catecholamine turnover. The data are interpreted to mean that an increase in the tyrosine concentration in the tissues does not result in an in vivo substrate inhibition of tyrosine hydroxylase. |
| doi_str_mv | 10.1111/j.1476-5381.1972.tb07268.x |
| format | Article |
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Under these conditions catecholamine concentrations in the brain and the heart remained unchanged even when the rats were maintained in a cold environment to increase catecholamine turnover. The data are interpreted to mean that an increase in the tyrosine concentration in the tissues does not result in an in vivo substrate inhibition of tyrosine hydroxylase.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1972.tb07268.x</identifier><identifier>PMID: 4148919</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Brain - metabolism ; Carbon Radioisotopes ; Catecholamines - metabolism ; Cycloheximide - pharmacology ; Dopamine - metabolism ; Female ; Myocardium - metabolism ; Norepinephrine - metabolism ; Rats ; Short Communications ; Tyrosine - blood ; Tyrosine - metabolism ; Tyrosine - pharmacology ; Tyrosine 3-Monooxygenase - metabolism</subject><ispartof>British journal of pharmacology, 1972-02, Vol.44 (2), p.307-310</ispartof><rights>1972 British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4778-f1027e0d765d5f801f98b50df6e4e897ff8faefcee4f1aafd55248f7f6b239933</citedby><cites>FETCH-LOGICAL-c4778-f1027e0d765d5f801f98b50df6e4e897ff8faefcee4f1aafd55248f7f6b239933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1666031/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1666031/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4148919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dairman, W.</creatorcontrib><title>Catecholamine concentrations and the activity of tyrosine hydroxylase after an increase in the concentration of tyrosine in rat tissues</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>The concentrations of tyrosine in rat plasma and brain were increased 2-7 fold by the administration of either L-tyrosine or cycloheximide. Under these conditions catecholamine concentrations in the brain and the heart remained unchanged even when the rats were maintained in a cold environment to increase catecholamine turnover. The data are interpreted to mean that an increase in the tyrosine concentration in the tissues does not result in an in vivo substrate inhibition of tyrosine hydroxylase.</description><subject>Animals</subject><subject>Brain - metabolism</subject><subject>Carbon Radioisotopes</subject><subject>Catecholamines - metabolism</subject><subject>Cycloheximide - pharmacology</subject><subject>Dopamine - metabolism</subject><subject>Female</subject><subject>Myocardium - metabolism</subject><subject>Norepinephrine - metabolism</subject><subject>Rats</subject><subject>Short Communications</subject><subject>Tyrosine - blood</subject><subject>Tyrosine - metabolism</subject><subject>Tyrosine - pharmacology</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUctOGzEUtSoqSGk_AWnEgt1M7XnYHhYgiNqChASLsrYczzVxNLHBdiDzBfw2HhJFzbLe2LrncY91EDoluCDp_FwUpGY0bypOCtKysogzzErKi_UXNNlBB2iCMWY5IZwfoW8hLDBOIGsO0WFNat6SdoLepzKCmrteLo2FTDmrwEYvo3E2ZNJ2WZxDJlU0ryYOmdNZHLwLI3c-dN6th16GRNARfKJnxioP48TYT-We4Z48EdI0iyaEFYTv6KuWfYAf2_sYPf7-9Xd6k9_d_7mdXt3lKiXnuSa4ZIA7Rpuu0RwT3fJZgztNoQbeMq25lqAVQK2JlLprmrLmmmk6K6u2rapjdLHxfV7NltBtsvXi2Zul9INw0oh9xJq5eHKvglBKcUWSwdnWwLuXFDyKpQkK-l5acKsgOGGspQwn4vmGqNKHgwe9W0KwGGsUCzF2JcauxFij2NYo1kl88m_MnXTbW8IvN_ib6WH4D2dx_XAzvqoPUvuzpA</recordid><startdate>197202</startdate><enddate>197202</enddate><creator>Dairman, W.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>197202</creationdate><title>Catecholamine concentrations and the activity of tyrosine hydroxylase after an increase in the concentration of tyrosine in rat tissues</title><author>Dairman, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4778-f1027e0d765d5f801f98b50df6e4e897ff8faefcee4f1aafd55248f7f6b239933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Animals</topic><topic>Brain - metabolism</topic><topic>Carbon Radioisotopes</topic><topic>Catecholamines - metabolism</topic><topic>Cycloheximide - pharmacology</topic><topic>Dopamine - metabolism</topic><topic>Female</topic><topic>Myocardium - metabolism</topic><topic>Norepinephrine - metabolism</topic><topic>Rats</topic><topic>Short Communications</topic><topic>Tyrosine - blood</topic><topic>Tyrosine - metabolism</topic><topic>Tyrosine - pharmacology</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dairman, W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dairman, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Catecholamine concentrations and the activity of tyrosine hydroxylase after an increase in the concentration of tyrosine in rat tissues</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1972-02</date><risdate>1972</risdate><volume>44</volume><issue>2</issue><spage>307</spage><epage>310</epage><pages>307-310</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>The concentrations of tyrosine in rat plasma and brain were increased 2-7 fold by the administration of either L-tyrosine or cycloheximide. Under these conditions catecholamine concentrations in the brain and the heart remained unchanged even when the rats were maintained in a cold environment to increase catecholamine turnover. The data are interpreted to mean that an increase in the tyrosine concentration in the tissues does not result in an in vivo substrate inhibition of tyrosine hydroxylase.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>4148919</pmid><doi>10.1111/j.1476-5381.1972.tb07268.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0007-1188 |
| ispartof | British journal of pharmacology, 1972-02, Vol.44 (2), p.307-310 |
| issn | 0007-1188 1476-5381 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Brain - metabolism Carbon Radioisotopes Catecholamines - metabolism Cycloheximide - pharmacology Dopamine - metabolism Female Myocardium - metabolism Norepinephrine - metabolism Rats Short Communications Tyrosine - blood Tyrosine - metabolism Tyrosine - pharmacology Tyrosine 3-Monooxygenase - metabolism |
| title | Catecholamine concentrations and the activity of tyrosine hydroxylase after an increase in the concentration of tyrosine in rat tissues |
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