NHE2-mediated bicarbonate reabsorption in the distal tubule of NHE3 null mice

NHE3 â/â mice display a profound defect in proximal tubule bicarbonate reabsorption but are only mildly acidotic owing to reduced glomerular filtration rate and enhanced H + secretion in distal nephron segments. In vivo microperfusion of rat distal tubules suggests that a significant fraction of...

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Veröffentlicht in:	The Journal of physiology 2004-12, Vol.561 (3), p.765-775
Hauptverfasser:	Bailey, Matthew A., Giebisch, Gerhard, Abbiati, Thecla, Aronson, Peter S., Gawenis, Lara R., Shull, Gary E., Wang, Tong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis - metabolism Animals Bicarbonates - metabolism Blood Pressure - drug effects Glomerular Filtration Rate - drug effects Guanidines - pharmacology Kidney Tubules, Distal - drug effects Kidney Tubules, Distal - metabolism Mice Mice, Knockout Potassium - metabolism Research Papers Sodium-Hydrogen Exchanger 3 Sodium-Hydrogen Exchangers - antagonists & inhibitors Sodium-Hydrogen Exchangers - genetics Sodium-Hydrogen Exchangers - physiology Sulfones - pharmacology
Online-Zugang:	Volltext
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