Dietary calcium, sex hormones, and bone mineral density in men
OBJECTIVE--To evaluate the factors that determine bone mineral density at axial and appendicular sites in normal men. DESIGN--Measurement of bone mineral density of the radius by single photon absorptiometry and of the lumbar spine and hip by dual photon absorptiometry to assess their relation with...
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| Veröffentlicht in: | BMJ 1990-05, Vol.300 (6736), p.1361-1364 |
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| creator | Kelly, P J Pocock, N A Sambrook, P N Eisman, J A |
| description | OBJECTIVE--To evaluate the factors that determine bone mineral density at axial and appendicular sites in normal men. DESIGN--Measurement of bone mineral density of the radius by single photon absorptiometry and of the lumbar spine and hip by dual photon absorptiometry to assess their relation with various determinants of bone mineral density. Dietary calcium was assessed from a questionnaire validated against a four day dietary record. SETTING--Local community, Sydney, Australia. PATIENTS--48 Men (aged 21-79, median 44) recruited from the local community including 35 male cotwins of twin pairs of differing sex recruited from the Australian National Health and Medical Research Council twin registry for epidemiological studies on determinants of bone mineral density. MAIN OUTCOME MEASURES--Bone mineral density of the axial and appendicular skeleton and its relation to age, anthropometric features, dietary calcium intake, and serum sex hormone concentrations. RESULTS--Dietary calcium intake (g/day) was a significant predictor of bone mineral density of axial bones, explaining 24% and 42% of the variance at the lumbar spine and femoral neck respectively. This effect was independent of weight. In contrast with the axial skeleton, bone mineral density at each forearm site was predicted by weight and an index of free testosterone but not by dietary calcium intake. CONCLUSIONS--Dietary calcium intake has a role in the determination or maintenance, or both, of the axial but not the appendicular skeleton in adult men. |
| doi_str_mv | 10.1136/bmj.300.6736.1361 |
| format | Article |
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DESIGN--Measurement of bone mineral density of the radius by single photon absorptiometry and of the lumbar spine and hip by dual photon absorptiometry to assess their relation with various determinants of bone mineral density. Dietary calcium was assessed from a questionnaire validated against a four day dietary record. SETTING--Local community, Sydney, Australia. PATIENTS--48 Men (aged 21-79, median 44) recruited from the local community including 35 male cotwins of twin pairs of differing sex recruited from the Australian National Health and Medical Research Council twin registry for epidemiological studies on determinants of bone mineral density. MAIN OUTCOME MEASURES--Bone mineral density of the axial and appendicular skeleton and its relation to age, anthropometric features, dietary calcium intake, and serum sex hormone concentrations. RESULTS--Dietary calcium intake (g/day) was a significant predictor of bone mineral density of axial bones, explaining 24% and 42% of the variance at the lumbar spine and femoral neck respectively. This effect was independent of weight. In contrast with the axial skeleton, bone mineral density at each forearm site was predicted by weight and an index of free testosterone but not by dietary calcium intake. CONCLUSIONS--Dietary calcium intake has a role in the determination or maintenance, or both, of the axial but not the appendicular skeleton in adult men.</description><identifier>ISSN: 0959-8138</identifier><identifier>ISSN: 0959-8146</identifier><identifier>EISSN: 1468-5833</identifier><identifier>EISSN: 1756-1833</identifier><identifier>DOI: 10.1136/bmj.300.6736.1361</identifier><identifier>PMID: 2142609</identifier><language>eng</language><publisher>London: British Medical Journal Publishing Group</publisher><subject>Adult ; Age Factors ; Aged ; Biological and medical sciences ; Body Constitution ; Bone Density ; Bones ; Calcium, Dietary - administration & dosage ; Dehydroepiandrosterone - analogs & derivatives ; Dehydroepiandrosterone - blood ; Dehydroepiandrosterone Sulfate ; Dietary calcium ; Dose-Response Relationship, Drug ; Estradiol - blood ; Femur - analysis ; Femur neck ; Forearm ; Fundamental and applied biological sciences. Psychology ; Gonadal Steroid Hormones - blood ; Hip fractures ; Humans ; Lumbar spine ; Lumbar Vertebrae - analysis ; Male ; Middle Aged ; Radius ; Radius - analysis ; Sex hormones ; Testosterone ; Testosterone - blood ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>BMJ, 1990-05, Vol.300 (6736), p.1361-1364</ispartof><rights>Copyright 1990 British Medical Journal</rights><rights>1993 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD May 26, 1990</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b579t-e3e3e4399d1139169b41e8c91a3badf465a195a00f1c82da37ccf2e553f98923</citedby><cites>FETCH-LOGICAL-b579t-e3e3e4399d1139169b41e8c91a3badf465a195a00f1c82da37ccf2e553f98923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/29707958$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/29707958$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4691639$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2142609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kelly, P J</creatorcontrib><creatorcontrib>Pocock, N A</creatorcontrib><creatorcontrib>Sambrook, P N</creatorcontrib><creatorcontrib>Eisman, J A</creatorcontrib><title>Dietary calcium, sex hormones, and bone mineral density in men</title><title>BMJ</title><addtitle>BMJ</addtitle><description>OBJECTIVE--To evaluate the factors that determine bone mineral density at axial and appendicular sites in normal men. DESIGN--Measurement of bone mineral density of the radius by single photon absorptiometry and of the lumbar spine and hip by dual photon absorptiometry to assess their relation with various determinants of bone mineral density. Dietary calcium was assessed from a questionnaire validated against a four day dietary record. SETTING--Local community, Sydney, Australia. PATIENTS--48 Men (aged 21-79, median 44) recruited from the local community including 35 male cotwins of twin pairs of differing sex recruited from the Australian National Health and Medical Research Council twin registry for epidemiological studies on determinants of bone mineral density. MAIN OUTCOME MEASURES--Bone mineral density of the axial and appendicular skeleton and its relation to age, anthropometric features, dietary calcium intake, and serum sex hormone concentrations. RESULTS--Dietary calcium intake (g/day) was a significant predictor of bone mineral density of axial bones, explaining 24% and 42% of the variance at the lumbar spine and femoral neck respectively. This effect was independent of weight. In contrast with the axial skeleton, bone mineral density at each forearm site was predicted by weight and an index of free testosterone but not by dietary calcium intake. CONCLUSIONS--Dietary calcium intake has a role in the determination or maintenance, or both, of the axial but not the appendicular skeleton in adult men.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Body Constitution</subject><subject>Bone Density</subject><subject>Bones</subject><subject>Calcium, Dietary - administration & dosage</subject><subject>Dehydroepiandrosterone - analogs & derivatives</subject><subject>Dehydroepiandrosterone - blood</subject><subject>Dehydroepiandrosterone Sulfate</subject><subject>Dietary calcium</subject><subject>Dose-Response Relationship, Drug</subject><subject>Estradiol - blood</subject><subject>Femur - analysis</subject><subject>Femur neck</subject><subject>Forearm</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonadal Steroid Hormones - blood</subject><subject>Hip fractures</subject><subject>Humans</subject><subject>Lumbar spine</subject><subject>Lumbar Vertebrae - analysis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radius</subject><subject>Radius - analysis</subject><subject>Sex hormones</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0959-8138</issn><issn>0959-8146</issn><issn>1468-5833</issn><issn>1756-1833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFUU1v1DAUtBBVWZX-AA5IkUCcNos_4q9LJdhCKargsuJqOY5DvSROayeo_fd90a62hUvlgy3PvNG8GYTeELwihImPdb9dMYxXQjKxgg_yAi1IJVTJFWMv0QJrrktFmHqFTnPeYowpk0oLfoyOKamowHqBzs6DH226L5ztXJj6ZZH9XXE9pH6IPi8LG5uihmfRh-iT7YrGxxzG-yLEovfxNTpqbZf96f4-QZuvXzbrb-XVz4vL9aersuZSj6VncCqmdQPONRG6rohXThPLatu0leCWaG4xbolTtLFMOtdSzzlrtdKUnaCznezNVPe-cT6O4MXcpNCDdzPYYP5FYrg2v4e_hghBtZQg8GEvkIbbyefR9CE733U2-mHKRmqlOITzLJFwQaXms6V3_xG3w5QihGCIlKKiikoOLLJjuTTknHx78EywmVs00KKBFs3coplbhJm3T5c9TOw7A_z9HrcZWmuTjS7kA60SEDDTjzLbPA7pUUVLDAsowMsdHvLo7w64TX9mL5KbH7_W5vOmqqT8zg0D_nLHnx0_v8UD0WjJ8g</recordid><startdate>19900526</startdate><enddate>19900526</enddate><creator>Kelly, P J</creator><creator>Pocock, N A</creator><creator>Sambrook, P N</creator><creator>Eisman, J A</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>LK8</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QP</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19900526</creationdate><title>Dietary calcium, sex hormones, and bone mineral density in men</title><author>Kelly, P J ; Pocock, N A ; Sambrook, P N ; Eisman, J A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b579t-e3e3e4399d1139169b41e8c91a3badf465a195a00f1c82da37ccf2e553f98923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Body Constitution</topic><topic>Bone Density</topic><topic>Bones</topic><topic>Calcium, Dietary - administration & dosage</topic><topic>Dehydroepiandrosterone - analogs & derivatives</topic><topic>Dehydroepiandrosterone - blood</topic><topic>Dehydroepiandrosterone Sulfate</topic><topic>Dietary calcium</topic><topic>Dose-Response Relationship, Drug</topic><topic>Estradiol - blood</topic><topic>Femur - analysis</topic><topic>Femur neck</topic><topic>Forearm</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonadal Steroid Hormones - blood</topic><topic>Hip fractures</topic><topic>Humans</topic><topic>Lumbar spine</topic><topic>Lumbar Vertebrae - analysis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Radius</topic><topic>Radius - analysis</topic><topic>Sex hormones</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kelly, P J</creatorcontrib><creatorcontrib>Pocock, N A</creatorcontrib><creatorcontrib>Sambrook, P N</creatorcontrib><creatorcontrib>Eisman, J A</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kelly, P J</au><au>Pocock, N A</au><au>Sambrook, P N</au><au>Eisman, J A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary calcium, sex hormones, and bone mineral density in men</atitle><jtitle>BMJ</jtitle><addtitle>BMJ</addtitle><date>1990-05-26</date><risdate>1990</risdate><volume>300</volume><issue>6736</issue><spage>1361</spage><epage>1364</epage><pages>1361-1364</pages><issn>0959-8138</issn><issn>0959-8146</issn><eissn>1468-5833</eissn><eissn>1756-1833</eissn><abstract>OBJECTIVE--To evaluate the factors that determine bone mineral density at axial and appendicular sites in normal men. DESIGN--Measurement of bone mineral density of the radius by single photon absorptiometry and of the lumbar spine and hip by dual photon absorptiometry to assess their relation with various determinants of bone mineral density. Dietary calcium was assessed from a questionnaire validated against a four day dietary record. SETTING--Local community, Sydney, Australia. PATIENTS--48 Men (aged 21-79, median 44) recruited from the local community including 35 male cotwins of twin pairs of differing sex recruited from the Australian National Health and Medical Research Council twin registry for epidemiological studies on determinants of bone mineral density. MAIN OUTCOME MEASURES--Bone mineral density of the axial and appendicular skeleton and its relation to age, anthropometric features, dietary calcium intake, and serum sex hormone concentrations. RESULTS--Dietary calcium intake (g/day) was a significant predictor of bone mineral density of axial bones, explaining 24% and 42% of the variance at the lumbar spine and femoral neck respectively. This effect was independent of weight. In contrast with the axial skeleton, bone mineral density at each forearm site was predicted by weight and an index of free testosterone but not by dietary calcium intake. CONCLUSIONS--Dietary calcium intake has a role in the determination or maintenance, or both, of the axial but not the appendicular skeleton in adult men.</abstract><cop>London</cop><pub>British Medical Journal Publishing Group</pub><pmid>2142609</pmid><doi>10.1136/bmj.300.6736.1361</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0959-8138 |
| ispartof | BMJ, 1990-05, Vol.300 (6736), p.1361-1364 |
| issn | 0959-8138 0959-8146 1468-5833 1756-1833 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1662977 |
| source | MEDLINE; Jstor Complete Legacy; Alma/SFX Local Collection |
| subjects | Adult Age Factors Aged Biological and medical sciences Body Constitution Bone Density Bones Calcium, Dietary - administration & dosage Dehydroepiandrosterone - analogs & derivatives Dehydroepiandrosterone - blood Dehydroepiandrosterone Sulfate Dietary calcium Dose-Response Relationship, Drug Estradiol - blood Femur - analysis Femur neck Forearm Fundamental and applied biological sciences. Psychology Gonadal Steroid Hormones - blood Hip fractures Humans Lumbar spine Lumbar Vertebrae - analysis Male Middle Aged Radius Radius - analysis Sex hormones Testosterone Testosterone - blood Vertebrates: osteoarticular system, musculoskeletal system |
| title | Dietary calcium, sex hormones, and bone mineral density in men |
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