A role for maternal β-catenin in early mesoderm induction in Xenopus
Mesoderm formation results from an inducing process that requires maternal and zygotic FGF/MAPK and TGFβ activities, while maternal activation of the Wnt/β‐catenin pathway determines the anterior–dorsal axis. Here, we show a new role of Wnt/β‐catenin signaling in mesoderm induction. We find that mat...
Gespeichert in:
| Veröffentlicht in: | The EMBO journal 2003-07, Vol.22 (13), p.3303-3313 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3313 |
|---|---|
| container_issue | 13 |
| container_start_page | 3303 |
| container_title | The EMBO journal |
| container_volume | 22 |
| creator | Schohl, Anne Fagotto, François |
| description | Mesoderm formation results from an inducing process that requires maternal and zygotic FGF/MAPK and TGFβ activities, while maternal activation of the Wnt/β‐catenin pathway determines the anterior–dorsal axis. Here, we show a new role of Wnt/β‐catenin signaling in mesoderm induction. We find that maternal β‐catenin signaling is not only active dorsally but also all around the equatorial region, coinciding with the prospective mesoderm. Maternal β‐catenin function is required both for expression of dorsal genes and for activation of MAPK and the mesodermal markers Xbra and eomesodermin. β‐catenin acts in a non‐ cell‐autonomous manner upstream of zygotic FGF and nodal signals. The Wnt/β‐catenin activity in the equatorial region of the early embryo is the first example of a maternally provided mesoderm inducer restricted to the prospective mesoderm. |
| doi_str_mv | 10.1093/emboj/cdg328 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_165652</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17286451</sourcerecordid><originalsourceid>FETCH-LOGICAL-i4148-f8c4b14d7279c327932ddb684646afe900e4e007c2da3ddf3713e897f26df0973</originalsourceid><addsrcrecordid>eNqFkctu1DAYhS1ERaeFHWuUFbu0vl8WLEoYClU7bECwszzxnyFDEk_tBJjX4kF4JtxOb0hISJZt-ZzPPvJB6DnBRwQbdgz9MqyPa79iVD9CM8IlLilW4jGaYSpJyYk2--ggpTXGWGhFnqB9QjUzxtAZmp8UMXRQNCEWvRshDq4rfv8q67wf2qHIA1zstkUPKXiIfT7xUz224Vr7AkPYTOkp2mtcl-DZzXqIPr2df6zelecfTt9XJ-dlywnXZaNrviTcK6pMzfLEqPdLqbnk0jVgMAYOGKuaese8b5giDLRRDZW-wUaxQ_Rqd-9mWvbgaxjG6Dq7iW3v4tYG19q_laH9alfhuyVSSEEz__KGj-FygjTavk01dJ0bIEzJKsYZoVz-10gU1ZILko0vHia6i3L7w9kgdoYfbQfbex3bq_bsdXt2156dX7w-U8LkoDpz5Y5LGRlWEO06TFftpH-y9_42jfDz7h0Xv1mpmBL28-LUyupi8aYSlV2wP05hryE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17286451</pqid></control><display><type>article</type><title>A role for maternal β-catenin in early mesoderm induction in Xenopus</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Schohl, Anne ; Fagotto, François</creator><creatorcontrib>Schohl, Anne ; Fagotto, François</creatorcontrib><description>Mesoderm formation results from an inducing process that requires maternal and zygotic FGF/MAPK and TGFβ activities, while maternal activation of the Wnt/β‐catenin pathway determines the anterior–dorsal axis. Here, we show a new role of Wnt/β‐catenin signaling in mesoderm induction. We find that maternal β‐catenin signaling is not only active dorsally but also all around the equatorial region, coinciding with the prospective mesoderm. Maternal β‐catenin function is required both for expression of dorsal genes and for activation of MAPK and the mesodermal markers Xbra and eomesodermin. β‐catenin acts in a non‐ cell‐autonomous manner upstream of zygotic FGF and nodal signals. The Wnt/β‐catenin activity in the equatorial region of the early embryo is the first example of a maternally provided mesoderm inducer restricted to the prospective mesoderm.</description><identifier>ISSN: 0261-4189</identifier><identifier>EISSN: 1460-2075</identifier><identifier>DOI: 10.1093/emboj/cdg328</identifier><identifier>PMID: 12839992</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Base Sequence ; beta -catenin ; Blotting, Western ; Brachyury protein ; Cytoskeletal Proteins - genetics ; Cytoskeletal Proteins - metabolism ; Cytoskeletal Proteins - physiology ; DNA Primers ; EMBO11 ; EMBO37 ; embryonic development ; Embryonic Induction ; Enzyme Activation ; eomesodermin gene ; Female ; FGF ; Fibroblast Growth Factors - metabolism ; Fluorescent Antibody Technique ; Genomic Imprinting ; MAPK ; Mesoderm ; Mitogen-Activated Protein Kinases - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction ; Trans-Activators - genetics ; Trans-Activators - metabolism ; Trans-Activators - physiology ; Wnt pathway ; Xenopus ; Xenopus Proteins ; Xnr</subject><ispartof>The EMBO journal, 2003-07, Vol.22 (13), p.3303-3313</ispartof><rights>European Molecular Biology Organization 2003</rights><rights>Copyright © 2003 European Molecular Biology Organization</rights><rights>Copyright © 2003 European Molecular Biology Organization 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC165652/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC165652/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12839992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schohl, Anne</creatorcontrib><creatorcontrib>Fagotto, François</creatorcontrib><title>A role for maternal β-catenin in early mesoderm induction in Xenopus</title><title>The EMBO journal</title><addtitle>EMBO J</addtitle><addtitle>EMBO J</addtitle><description>Mesoderm formation results from an inducing process that requires maternal and zygotic FGF/MAPK and TGFβ activities, while maternal activation of the Wnt/β‐catenin pathway determines the anterior–dorsal axis. Here, we show a new role of Wnt/β‐catenin signaling in mesoderm induction. We find that maternal β‐catenin signaling is not only active dorsally but also all around the equatorial region, coinciding with the prospective mesoderm. Maternal β‐catenin function is required both for expression of dorsal genes and for activation of MAPK and the mesodermal markers Xbra and eomesodermin. β‐catenin acts in a non‐ cell‐autonomous manner upstream of zygotic FGF and nodal signals. The Wnt/β‐catenin activity in the equatorial region of the early embryo is the first example of a maternally provided mesoderm inducer restricted to the prospective mesoderm.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>beta -catenin</subject><subject>Blotting, Western</subject><subject>Brachyury protein</subject><subject>Cytoskeletal Proteins - genetics</subject><subject>Cytoskeletal Proteins - metabolism</subject><subject>Cytoskeletal Proteins - physiology</subject><subject>DNA Primers</subject><subject>EMBO11</subject><subject>EMBO37</subject><subject>embryonic development</subject><subject>Embryonic Induction</subject><subject>Enzyme Activation</subject><subject>eomesodermin gene</subject><subject>Female</subject><subject>FGF</subject><subject>Fibroblast Growth Factors - metabolism</subject><subject>Fluorescent Antibody Technique</subject><subject>Genomic Imprinting</subject><subject>MAPK</subject><subject>Mesoderm</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Signal Transduction</subject><subject>Trans-Activators - genetics</subject><subject>Trans-Activators - metabolism</subject><subject>Trans-Activators - physiology</subject><subject>Wnt pathway</subject><subject>Xenopus</subject><subject>Xenopus Proteins</subject><subject>Xnr</subject><issn>0261-4189</issn><issn>1460-2075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAYhS1ERaeFHWuUFbu0vl8WLEoYClU7bECwszzxnyFDEk_tBJjX4kF4JtxOb0hISJZt-ZzPPvJB6DnBRwQbdgz9MqyPa79iVD9CM8IlLilW4jGaYSpJyYk2--ggpTXGWGhFnqB9QjUzxtAZmp8UMXRQNCEWvRshDq4rfv8q67wf2qHIA1zstkUPKXiIfT7xUz224Vr7AkPYTOkp2mtcl-DZzXqIPr2df6zelecfTt9XJ-dlywnXZaNrviTcK6pMzfLEqPdLqbnk0jVgMAYOGKuaese8b5giDLRRDZW-wUaxQ_Rqd-9mWvbgaxjG6Dq7iW3v4tYG19q_laH9alfhuyVSSEEz__KGj-FygjTavk01dJ0bIEzJKsYZoVz-10gU1ZILko0vHia6i3L7w9kgdoYfbQfbex3bq_bsdXt2156dX7w-U8LkoDpz5Y5LGRlWEO06TFftpH-y9_42jfDz7h0Xv1mpmBL28-LUyupi8aYSlV2wP05hryE</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>Schohl, Anne</creator><creator>Fagotto, François</creator><general>John Wiley & Sons, Ltd</general><general>Nature Publishing Group UK</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20030701</creationdate><title>A role for maternal β-catenin in early mesoderm induction in Xenopus</title><author>Schohl, Anne ; Fagotto, François</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i4148-f8c4b14d7279c327932ddb684646afe900e4e007c2da3ddf3713e897f26df0973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>beta -catenin</topic><topic>Blotting, Western</topic><topic>Brachyury protein</topic><topic>Cytoskeletal Proteins - genetics</topic><topic>Cytoskeletal Proteins - metabolism</topic><topic>Cytoskeletal Proteins - physiology</topic><topic>DNA Primers</topic><topic>EMBO11</topic><topic>EMBO37</topic><topic>embryonic development</topic><topic>Embryonic Induction</topic><topic>Enzyme Activation</topic><topic>eomesodermin gene</topic><topic>Female</topic><topic>FGF</topic><topic>Fibroblast Growth Factors - metabolism</topic><topic>Fluorescent Antibody Technique</topic><topic>Genomic Imprinting</topic><topic>MAPK</topic><topic>Mesoderm</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Signal Transduction</topic><topic>Trans-Activators - genetics</topic><topic>Trans-Activators - metabolism</topic><topic>Trans-Activators - physiology</topic><topic>Wnt pathway</topic><topic>Xenopus</topic><topic>Xenopus Proteins</topic><topic>Xnr</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schohl, Anne</creatorcontrib><creatorcontrib>Fagotto, François</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The EMBO journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schohl, Anne</au><au>Fagotto, François</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A role for maternal β-catenin in early mesoderm induction in Xenopus</atitle><jtitle>The EMBO journal</jtitle><stitle>EMBO J</stitle><addtitle>EMBO J</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>22</volume><issue>13</issue><spage>3303</spage><epage>3313</epage><pages>3303-3313</pages><issn>0261-4189</issn><eissn>1460-2075</eissn><abstract>Mesoderm formation results from an inducing process that requires maternal and zygotic FGF/MAPK and TGFβ activities, while maternal activation of the Wnt/β‐catenin pathway determines the anterior–dorsal axis. Here, we show a new role of Wnt/β‐catenin signaling in mesoderm induction. We find that maternal β‐catenin signaling is not only active dorsally but also all around the equatorial region, coinciding with the prospective mesoderm. Maternal β‐catenin function is required both for expression of dorsal genes and for activation of MAPK and the mesodermal markers Xbra and eomesodermin. β‐catenin acts in a non‐ cell‐autonomous manner upstream of zygotic FGF and nodal signals. The Wnt/β‐catenin activity in the equatorial region of the early embryo is the first example of a maternally provided mesoderm inducer restricted to the prospective mesoderm.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>12839992</pmid><doi>10.1093/emboj/cdg328</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0261-4189 |
| ispartof | The EMBO journal, 2003-07, Vol.22 (13), p.3303-3313 |
| issn | 0261-4189 1460-2075 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_165652 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Base Sequence beta -catenin Blotting, Western Brachyury protein Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Cytoskeletal Proteins - physiology DNA Primers EMBO11 EMBO37 embryonic development Embryonic Induction Enzyme Activation eomesodermin gene Female FGF Fibroblast Growth Factors - metabolism Fluorescent Antibody Technique Genomic Imprinting MAPK Mesoderm Mitogen-Activated Protein Kinases - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Trans-Activators - genetics Trans-Activators - metabolism Trans-Activators - physiology Wnt pathway Xenopus Xenopus Proteins Xnr |
| title | A role for maternal β-catenin in early mesoderm induction in Xenopus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T05%3A18%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20role%20for%20maternal%20%CE%B2-catenin%20in%20early%20mesoderm%20induction%20in%20Xenopus&rft.jtitle=The%20EMBO%20journal&rft.au=Schohl,%20Anne&rft.date=2003-07-01&rft.volume=22&rft.issue=13&rft.spage=3303&rft.epage=3313&rft.pages=3303-3313&rft.issn=0261-4189&rft.eissn=1460-2075&rft_id=info:doi/10.1093/emboj/cdg328&rft_dat=%3Cproquest_pubme%3E17286451%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17286451&rft_id=info:pmid/12839992&rfr_iscdi=true |