Structure of a trapped endonuclease III-DNA covalent intermediate

Nearly all cells express proteins that confer resistance to the mutagenic effects of oxidative DNA damage. The primary defense against the toxicity of oxidative nucleobase lesions in DNA is the base‐excision repair (BER) pathway. Endonuclease III (EndoIII) is a [4Fe–4S] cluster‐containing DNA glycos...

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Veröffentlicht in:	The EMBO journal 2003-07, Vol.22 (13), p.3461-3471
Hauptverfasser:	Fromme, J.Christopher, Verdine, Gregory L.
Format:	Artikel
Sprache:	eng
Schlagworte:	[4Fe-4S] cluster Base Sequence Binding Sites crystal structure Deoxyribonuclease (Pyrimidine Dimer) Deoxyribonucleic acid DNA DNA glycosylase DNA Primers DNA repair EMBO13 EMBO40 Endodeoxyribonucleases - chemistry Endodeoxyribonucleases - metabolism endonuclease III Escherichia coli Proteins Humans Iron-Sulfur Proteins - chemistry Iron-Sulfur Proteins - metabolism Lesions Models, Molecular Mutation Neoplasms - genetics Neoplasms - metabolism Nucleic Acid Conformation Protein Binding Protein Conformation
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