Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees

To examine the effect of transforming growth factor (TGF)-beta1 on the regulation of cartilage synthesis and other articular pathologies, we used adenovirus-mediated intra-articular gene transfer of TGF-beta1 to both naïve and arthritic rabbit knee joints. Increasing doses of adenoviral vector expre...

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Veröffentlicht in:	Arthritis research & therapy 2003-01, Vol.5 (3), p.R132-R139, Article R132
Hauptverfasser:	Mi, Zhibao, Ghivizzani, Steven C, Lechman, Eric, Glorioso, Joseph C, Evans, Christopher H, Robbins, Paul D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - metabolism Adenoviruses Adjuvants, Immunologic - pharmacology Analysis Animals Arthritis, Experimental - immunology Arthritis, Experimental - pathology Arthritis, Experimental - therapy Bone morphogenetic proteins Cartilage - drug effects Cartilage - metabolism Control Disease Models, Animal Dose-Response Relationship, Immunologic Edema - etiology Gene Expression Regulation, Viral - genetics Gene therapy Gene Transfer Techniques Genetic Therapy - adverse effects Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - biosynthesis Genetic Vectors - therapeutic use Glycosaminoglycans - antagonists & inhibitors Glycosaminoglycans - metabolism Humans Identification and classification Injections, Intra-Articular Knee Joint - chemistry Knee Joint - drug effects Knee Joint - metabolism Knee Joint - pathology Leukocytes - drug effects Leukocytes - physiology Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Patient outcomes Rabbits Transforming Growth Factor beta - adverse effects Transforming Growth Factor beta - biosynthesis Transforming Growth Factor beta - genetics Transforming Growth Factor beta - therapeutic use Transforming Growth Factor beta1 Transforming growth factors
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