Deubiquitination of type 2 iodothyronine deiodinase by von Hippel–Lindau protein–interacting deubiquitinating enzymes regulates thyroid hormone activation

The type 2 iodothyronine deiodinase (D2) is an integral membrane ER-resident selenoenzyme that activates the pro-hormone thyroxine (T4) and supplies most of the 3,5,3′-triiodothyronine (T3) that is essential for brain development. D2 is inactivated by selective conjugation to ubiquitin, a process ac...

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Veröffentlicht in:	The Journal of clinical investigation 2003-07, Vol.112 (2), p.189-196
Hauptverfasser:	Curcio-Morelli, Cyntia, Zavacki, Ann Marie, Christofollete, Marcelo, Gereben, Balazs, de Freitas, Beatriz C.G., Harney, John W., Li, Zaibo, Wu, Guan, Bianco, Antonio C.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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