Intestinal Metabolism
The anatomy of the intestine is outlined. The kinetics of cell proliferation, differentiation, and migration in intestinal epithelium are described. The distribution of cell types between the proliferation and differentiation compartments of the epithelium is summarized. Seven preparations of intest...
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| Veröffentlicht in: | Environmental health perspectives 1979-12, Vol.33, p.25-35 |
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| container_title | Environmental health perspectives |
| container_volume | 33 |
| creator | Porteous, John W. |
| description | The anatomy of the intestine is outlined. The kinetics of cell proliferation, differentiation, and migration in intestinal epithelium are described. The distribution of cell types between the proliferation and differentiation compartments of the epithelium is summarized. Seven preparations of intestine in current use for metabolic studies are listed. An outline review is presented of recent results on glucose, amino acid and ketone body metabolism obtained with three of these preparations: the ligature-isolated loop of intestine in vivo; the vascularly and luminally perfused intestine in vitro; and suspensions of respiring intestinal epithelial cells in vitro. Reasons are given for thinking that these experimental systems are among the most useful currently available for metabolic studies, perhaps especially in the investigation of the metabolic fate of potentially toxic materials to which animal species may be exposed. |
| doi_str_mv | 10.1289/ehp.793325 |
| format | Article |
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The kinetics of cell proliferation, differentiation, and migration in intestinal epithelium are described. The distribution of cell types between the proliferation and differentiation compartments of the epithelium is summarized. Seven preparations of intestine in current use for metabolic studies are listed. An outline review is presented of recent results on glucose, amino acid and ketone body metabolism obtained with three of these preparations: the ligature-isolated loop of intestine in vivo; the vascularly and luminally perfused intestine in vitro; and suspensions of respiring intestinal epithelial cells in vitro. Reasons are given for thinking that these experimental systems are among the most useful currently available for metabolic studies, perhaps especially in the investigation of the metabolic fate of potentially toxic materials to which animal species may be exposed.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.793325</identifier><identifier>PMID: 540620</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>Amino Acids - metabolism ; Animals ; Biological Transport, Active ; Cell Differentiation ; Cell Movement ; Cellular differentiation ; Epithelial Cells ; Exocrine cells ; Fatty Acids - metabolism ; Glucose - metabolism ; Intestinal Absorption ; Intestinal Mucosa - anatomy & histology ; Intestinal Mucosa - metabolism ; Intestines ; Intestines - anatomy & histology ; Jejunum - metabolism ; Ketone Bodies - metabolism ; Lactates ; Metabolism ; Microvilli ; Mitosis ; Models, Biological ; Perfusion ; Small intestine ; Stem cells ; Target Organ Toxicity: Intestine. Raleigh, North Carolina May 24-25, 1979</subject><ispartof>Environmental health perspectives, 1979-12, Vol.33, p.25-35</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3165-2f9e9396289befeb5782e9c9e26523e2a6b47871b56b6b3ff4ef4de5662396153</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3429069$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3429069$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,864,885,27923,27924,53790,53792,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/540620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Porteous, John W.</creatorcontrib><title>Intestinal Metabolism</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>The anatomy of the intestine is outlined. The kinetics of cell proliferation, differentiation, and migration in intestinal epithelium are described. The distribution of cell types between the proliferation and differentiation compartments of the epithelium is summarized. Seven preparations of intestine in current use for metabolic studies are listed. An outline review is presented of recent results on glucose, amino acid and ketone body metabolism obtained with three of these preparations: the ligature-isolated loop of intestine in vivo; the vascularly and luminally perfused intestine in vitro; and suspensions of respiring intestinal epithelial cells in vitro. Reasons are given for thinking that these experimental systems are among the most useful currently available for metabolic studies, perhaps especially in the investigation of the metabolic fate of potentially toxic materials to which animal species may be exposed.</description><subject>Amino Acids - metabolism</subject><subject>Animals</subject><subject>Biological Transport, Active</subject><subject>Cell Differentiation</subject><subject>Cell Movement</subject><subject>Cellular differentiation</subject><subject>Epithelial Cells</subject><subject>Exocrine cells</subject><subject>Fatty Acids - metabolism</subject><subject>Glucose - metabolism</subject><subject>Intestinal Absorption</subject><subject>Intestinal Mucosa - anatomy & histology</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestines</subject><subject>Intestines - anatomy & histology</subject><subject>Jejunum - metabolism</subject><subject>Ketone Bodies - metabolism</subject><subject>Lactates</subject><subject>Metabolism</subject><subject>Microvilli</subject><subject>Mitosis</subject><subject>Models, Biological</subject><subject>Perfusion</subject><subject>Small intestine</subject><subject>Stem cells</subject><subject>Target Organ Toxicity: Intestine. Raleigh, North Carolina May 24-25, 1979</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AQhhfxq1YvgjcPHjwJqbuz2UnmIkjxo1DxoudlN521KWlSslHw3xuJlHqawzvvM8MjxLmSEwU53fJyM8lIazB7YqSMgYQI0n0xkpJUghmaY3ES40pKqXLEI3FoUokgR-JiVnccu7J21dULd843VRnXp-IguCry2d8ci_fHh7fpczJ_fZpN7-dJoRWaBAIxacL-Bc-BvclyYCqIAQ1oBoc-zfJMeYMevQ4h5ZAu2CBC31JGj8XdwN18-jUvCq671lV205Zr137bxpX2f1KXS_vRfFmFOleKesDNACjaJsaWw7arpP1VY3s1dlDTL1_uXtuuDi76-HqIV7Fr2l0QaJlZnQJJJP0D5n9png</recordid><startdate>19791201</startdate><enddate>19791201</enddate><creator>Porteous, John W.</creator><general>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>19791201</creationdate><title>Intestinal Metabolism</title><author>Porteous, John W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3165-2f9e9396289befeb5782e9c9e26523e2a6b47871b56b6b3ff4ef4de5662396153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Amino Acids - metabolism</topic><topic>Animals</topic><topic>Biological Transport, Active</topic><topic>Cell Differentiation</topic><topic>Cell Movement</topic><topic>Cellular differentiation</topic><topic>Epithelial Cells</topic><topic>Exocrine cells</topic><topic>Fatty Acids - metabolism</topic><topic>Glucose - metabolism</topic><topic>Intestinal Absorption</topic><topic>Intestinal Mucosa - anatomy & histology</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestines</topic><topic>Intestines - anatomy & histology</topic><topic>Jejunum - metabolism</topic><topic>Ketone Bodies - metabolism</topic><topic>Lactates</topic><topic>Metabolism</topic><topic>Microvilli</topic><topic>Mitosis</topic><topic>Models, Biological</topic><topic>Perfusion</topic><topic>Small intestine</topic><topic>Stem cells</topic><topic>Target Organ Toxicity: Intestine. Raleigh, North Carolina May 24-25, 1979</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Porteous, John W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Porteous, John W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal Metabolism</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>1979-12-01</date><risdate>1979</risdate><volume>33</volume><spage>25</spage><epage>35</epage><pages>25-35</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>The anatomy of the intestine is outlined. The kinetics of cell proliferation, differentiation, and migration in intestinal epithelium are described. The distribution of cell types between the proliferation and differentiation compartments of the epithelium is summarized. Seven preparations of intestine in current use for metabolic studies are listed. An outline review is presented of recent results on glucose, amino acid and ketone body metabolism obtained with three of these preparations: the ligature-isolated loop of intestine in vivo; the vascularly and luminally perfused intestine in vitro; and suspensions of respiring intestinal epithelial cells in vitro. Reasons are given for thinking that these experimental systems are among the most useful currently available for metabolic studies, perhaps especially in the investigation of the metabolic fate of potentially toxic materials to which animal species may be exposed.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>540620</pmid><doi>10.1289/ehp.793325</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 1979-12, Vol.33, p.25-35 |
| issn | 0091-6765 1552-9924 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1638119 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Amino Acids - metabolism Animals Biological Transport, Active Cell Differentiation Cell Movement Cellular differentiation Epithelial Cells Exocrine cells Fatty Acids - metabolism Glucose - metabolism Intestinal Absorption Intestinal Mucosa - anatomy & histology Intestinal Mucosa - metabolism Intestines Intestines - anatomy & histology Jejunum - metabolism Ketone Bodies - metabolism Lactates Metabolism Microvilli Mitosis Models, Biological Perfusion Small intestine Stem cells Target Organ Toxicity: Intestine. Raleigh, North Carolina May 24-25, 1979 |
| title | Intestinal Metabolism |
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