PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

Maintaining muscle size and fiber composition requires contractile activity. Increased activity stimulates expression of the transcriptional coactivator PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1α), which promotes fiber-type switching from glycolytic toward more oxidative fib...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-10, Vol.103 (44), p.16260-16265
Hauptverfasser:	Sandri, Marco, Lin, Jiandie, Handschin, Christoph, Yang, Wenli, Arany, Zoltan P., Lecker, Stewart H., Goldberg, Alfred L., Spiegelman, Bruce M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences
Online-Zugang:	Volltext
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