Sphingosine 1-phosphate induces myoblast differentiation through Cx43 protein expression: a role for a gap junction-dependent and -independent function

Although sphingosine 1-phosphate (S1P) has been considered a potent regulator of skeletal muscle biology, acting as a physiological anti-mitogenic and prodifferentiating agent, its downstream effectors are poorly known. In the present study, we provide experimental evidence for a novel mechanism by...

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Veröffentlicht in:	Molecular biology of the cell 2006-11, Vol.17 (11), p.4896-4910
Hauptverfasser:	Squecco, R, Sassoli, C, Nuti, F, Martinesi, M, Chellini, F, Nosi, D, Zecchi-Orlandini, S, Francini, F, Formigli, L, Meacci, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers Calcium - metabolism Cell Differentiation - drug effects Connexin 43 - metabolism Cytoskeletal Proteins - metabolism Down-Regulation - drug effects Electric Conductivity Enzyme Inhibitors - pharmacology Gap Junctions - drug effects Gene Expression - drug effects Kinetics Lysophospholipids - pharmacology Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Mutant Proteins - metabolism Myoblasts, Skeletal - cytology Myoblasts, Skeletal - drug effects Myogenin - metabolism p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Protein Binding - drug effects Protein Transport - drug effects Sphingosine - analogs & derivatives Sphingosine - pharmacology
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