Nonadaptive regulation of ERK2 in Dictyostelium: implications for mechanisms of cAMP relay

It is assumed that ERK2 in Dictyostelium is subject to adaptive regulation in response to constant extracellular ligand stimulation. We now show, to the contrary, that ERK2 remains active under continuous stimulation, differing from most ligand-activated pathways in chemotactically competent Dictyos...

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Veröffentlicht in:	Molecular biology of the cell 2006-10, Vol.17 (10), p.4220-4227
Hauptverfasser:	Brzostowski, Joseph A, Kimmel, Alan R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemotaxis Cyclic AMP - physiology Cyclic AMP-Dependent Protein Kinases - physiology Dictyostelium Dictyostelium - enzymology Dictyostelium - growth & development Gene Expression Regulation, Developmental Ligands MAP Kinase Signaling System Mitogen-Activated Protein Kinase 1 - metabolism Models, Biological Phosphorylation
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