Polymorphisms within inflammatory genes and colorectal cancer
Chronic inflammation is a risk factor for colorectal cancer and polymorphisms in the inflammatory genes could modulate the levels of inflammation. We have investigated ten single nucleotide polymorphisms (SNPs) in the following inflammation-related genes: TLR4 (Asp299Gly), CD14 (-260 T>C), MCP1 (...
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| Veröffentlicht in: | Journal of negative results in biomedicine 2006-10, Vol.5 (1), p.15-15, Article 15 |
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| creator | Landi, Stefano Gemignani, Federica Bottari, Fabio Gioia-Patricola, Lydie Guino, Elisabet Cambray, María Biondo, Sebastiano Capella, Gabriel Boldrini, Laura Canzian, Federico Moreno, Victor |
| description | Chronic inflammation is a risk factor for colorectal cancer and polymorphisms in the inflammatory genes could modulate the levels of inflammation. We have investigated ten single nucleotide polymorphisms (SNPs) in the following inflammation-related genes: TLR4 (Asp299Gly), CD14 (-260 T>C), MCP1 (-2518 A>G), IL12A (+7506 A>T, +8707 A>G, +9177 T>A, +9508 G>A), NOS2A (+524T>C), TNF (-857C>T), and PTGS1 (V444I) in 377 colorectal (CRC) cancer cases and 326 controls from Barcelona (Spain).
There was no statistically significant association between the SNPs investigated and colorectal cancer risk.
The lack of association may show that the inflammatory genes selected for this study are not involved in the carcinogenic process of colorectum. Alternatively, the negative results may derive from no particular biological effect of the analysed polymorphisms in relation to CRC. Otherwise, the eventual biological effect is so little to go undetected, unless analysing a much larger sample size. |
| doi_str_mv | 10.1186/1477-5751-5-15 |
| format | Article |
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There was no statistically significant association between the SNPs investigated and colorectal cancer risk.
The lack of association may show that the inflammatory genes selected for this study are not involved in the carcinogenic process of colorectum. Alternatively, the negative results may derive from no particular biological effect of the analysed polymorphisms in relation to CRC. Otherwise, the eventual biological effect is so little to go undetected, unless analysing a much larger sample size.</description><identifier>ISSN: 1477-5751</identifier><identifier>EISSN: 1477-5751</identifier><identifier>DOI: 10.1186/1477-5751-5-15</identifier><identifier>PMID: 17062130</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Colorectal cancer ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genetic variation ; Genotype ; Humans ; Inflammation - genetics ; Inflammation Mediators - metabolism ; Polymorphism, Genetic</subject><ispartof>Journal of negative results in biomedicine, 2006-10, Vol.5 (1), p.15-15, Article 15</ispartof><rights>COPYRIGHT 2006 BioMed Central Ltd.</rights><rights>Copyright © 2006 Landi et al; licensee BioMed Central Ltd. 2006 Landi et al; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b544t-6b23afa2b4ceb23fcc62c9b859834e5c499d37dbdd8900ba45e850935d1473773</citedby><cites>FETCH-LOGICAL-b544t-6b23afa2b4ceb23fcc62c9b859834e5c499d37dbdd8900ba45e850935d1473773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1634873/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1634873/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,24801,27924,27925,53791,53793,75738,75739</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17062130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Landi, Stefano</creatorcontrib><creatorcontrib>Gemignani, Federica</creatorcontrib><creatorcontrib>Bottari, Fabio</creatorcontrib><creatorcontrib>Gioia-Patricola, Lydie</creatorcontrib><creatorcontrib>Guino, Elisabet</creatorcontrib><creatorcontrib>Cambray, María</creatorcontrib><creatorcontrib>Biondo, Sebastiano</creatorcontrib><creatorcontrib>Capella, Gabriel</creatorcontrib><creatorcontrib>Boldrini, Laura</creatorcontrib><creatorcontrib>Canzian, Federico</creatorcontrib><creatorcontrib>Moreno, Victor</creatorcontrib><title>Polymorphisms within inflammatory genes and colorectal cancer</title><title>Journal of negative results in biomedicine</title><addtitle>J Negat Results Biomed</addtitle><description>Chronic inflammation is a risk factor for colorectal cancer and polymorphisms in the inflammatory genes could modulate the levels of inflammation. We have investigated ten single nucleotide polymorphisms (SNPs) in the following inflammation-related genes: TLR4 (Asp299Gly), CD14 (-260 T>C), MCP1 (-2518 A>G), IL12A (+7506 A>T, +8707 A>G, +9177 T>A, +9508 G>A), NOS2A (+524T>C), TNF (-857C>T), and PTGS1 (V444I) in 377 colorectal (CRC) cancer cases and 326 controls from Barcelona (Spain).
There was no statistically significant association between the SNPs investigated and colorectal cancer risk.
The lack of association may show that the inflammatory genes selected for this study are not involved in the carcinogenic process of colorectum. Alternatively, the negative results may derive from no particular biological effect of the analysed polymorphisms in relation to CRC. Otherwise, the eventual biological effect is so little to go undetected, unless analysing a much larger sample size.</description><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic variation</subject><subject>Genotype</subject><subject>Humans</subject><subject>Inflammation - genetics</subject><subject>Inflammation Mediators - metabolism</subject><subject>Polymorphism, Genetic</subject><issn>1477-5751</issn><issn>1477-5751</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kt1rHCEUxaU0NGnS1z6WgULfJtFRx_GhhSW0SSCQPjTP4jh3di1-bHQ2Zf_7OuySD5Lgg3Lv8ce5RxH6TPApIV17RpgQNRec1Lwm_B06eii8f3I-RB9z_otxg0UrPqBDInDbEIqP0Pff0W19TOuVzT5X_-y0sqGyYXTaez3FtK2WECBXOgyViS4mMJN2ldHBQDpBB6N2GT7t92N0--vnn_PL-vrm4up8cV33nLGpbvuG6lE3PTNQjqMxbWNk33HZUQbcMCkHKoZ-GDqJca8Zh45jSflQJqBC0GP0Y8ddb3oPg4EwJe3UOlmv01ZFbdXzTrArtYz3irSUdYIWwGIH6G18A_C8Y6JXc3xqjk9xRXhhfNubSPFuA3lS3mYDzukAcZMVKdNIJkgRft0Jl9qBKlnGgjSzWC0Il42QtJstnb6iKmsAb00MMNpSf-2CSTHnBOODfYLV_BleGv7yNLVH-f716X_E8rAL</recordid><startdate>20061024</startdate><enddate>20061024</enddate><creator>Landi, Stefano</creator><creator>Gemignani, Federica</creator><creator>Bottari, Fabio</creator><creator>Gioia-Patricola, Lydie</creator><creator>Guino, Elisabet</creator><creator>Cambray, María</creator><creator>Biondo, Sebastiano</creator><creator>Capella, Gabriel</creator><creator>Boldrini, Laura</creator><creator>Canzian, Federico</creator><creator>Moreno, Victor</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20061024</creationdate><title>Polymorphisms within inflammatory genes and colorectal cancer</title><author>Landi, Stefano ; Gemignani, Federica ; Bottari, Fabio ; Gioia-Patricola, Lydie ; Guino, Elisabet ; Cambray, María ; Biondo, Sebastiano ; Capella, Gabriel ; Boldrini, Laura ; Canzian, Federico ; Moreno, Victor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b544t-6b23afa2b4ceb23fcc62c9b859834e5c499d37dbdd8900ba45e850935d1473773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic variation</topic><topic>Genotype</topic><topic>Humans</topic><topic>Inflammation - genetics</topic><topic>Inflammation Mediators - metabolism</topic><topic>Polymorphism, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Landi, Stefano</creatorcontrib><creatorcontrib>Gemignani, Federica</creatorcontrib><creatorcontrib>Bottari, Fabio</creatorcontrib><creatorcontrib>Gioia-Patricola, Lydie</creatorcontrib><creatorcontrib>Guino, Elisabet</creatorcontrib><creatorcontrib>Cambray, María</creatorcontrib><creatorcontrib>Biondo, Sebastiano</creatorcontrib><creatorcontrib>Capella, Gabriel</creatorcontrib><creatorcontrib>Boldrini, Laura</creatorcontrib><creatorcontrib>Canzian, Federico</creatorcontrib><creatorcontrib>Moreno, Victor</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of negative results in biomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Landi, Stefano</au><au>Gemignani, Federica</au><au>Bottari, Fabio</au><au>Gioia-Patricola, Lydie</au><au>Guino, Elisabet</au><au>Cambray, María</au><au>Biondo, Sebastiano</au><au>Capella, Gabriel</au><au>Boldrini, Laura</au><au>Canzian, Federico</au><au>Moreno, Victor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms within inflammatory genes and colorectal cancer</atitle><jtitle>Journal of negative results in biomedicine</jtitle><addtitle>J Negat Results Biomed</addtitle><date>2006-10-24</date><risdate>2006</risdate><volume>5</volume><issue>1</issue><spage>15</spage><epage>15</epage><pages>15-15</pages><artnum>15</artnum><issn>1477-5751</issn><eissn>1477-5751</eissn><abstract>Chronic inflammation is a risk factor for colorectal cancer and polymorphisms in the inflammatory genes could modulate the levels of inflammation. We have investigated ten single nucleotide polymorphisms (SNPs) in the following inflammation-related genes: TLR4 (Asp299Gly), CD14 (-260 T>C), MCP1 (-2518 A>G), IL12A (+7506 A>T, +8707 A>G, +9177 T>A, +9508 G>A), NOS2A (+524T>C), TNF (-857C>T), and PTGS1 (V444I) in 377 colorectal (CRC) cancer cases and 326 controls from Barcelona (Spain).
There was no statistically significant association between the SNPs investigated and colorectal cancer risk.
The lack of association may show that the inflammatory genes selected for this study are not involved in the carcinogenic process of colorectum. Alternatively, the negative results may derive from no particular biological effect of the analysed polymorphisms in relation to CRC. Otherwise, the eventual biological effect is so little to go undetected, unless analysing a much larger sample size.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>17062130</pmid><doi>10.1186/1477-5751-5-15</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Genetic variation Genotype Humans Inflammation - genetics Inflammation Mediators - metabolism Polymorphism, Genetic |
| title | Polymorphisms within inflammatory genes and colorectal cancer |
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