Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1

The molecular nature of store-operated Ca2+-selective channels has remained an enigma, due largely to the continued inability to convincingly demonstrate Ca2+-selective store-operated currents resulting from exogenous expression of known genes. Recent findings have implicated two proteins, Stim1 and...

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Veröffentlicht in:	The Journal of biological chemistry 2006-08, Vol.281 (34), p.24979-24990
Hauptverfasser:	Mercer, Jason C., DeHaven, Wayne I., Smyth, Jeremy T., Wedel, Barbara, Boyles, Rebecca R., Bird, Gary S., Putney, James W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport Calcium - metabolism Calcium Channels Calcium Signaling Cell Line Cell Membrane - metabolism Endoplasmic Reticulum - metabolism Humans Membrane Proteins - physiology Neoplasm Proteins - physiology ORAI1 Protein ORAI2 Protein Stromal Interaction Molecule 1
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