Quantification of enterochromaffin cells with serotonin immunoreactivity in the duodenal mucosa in coeliac disease
Enterochromaffin cells in the duodenal mucosa were stained by using a monoclonal antibody against serotonin immunoreactive sites and an indirect immunoperoxidase technique. A semi-automatic image analysing system showed increased numbers of these cells in patients with untreated coeliac disease comp...
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| Veröffentlicht in: | Archives of disease in childhood 1984-06, Vol.59 (6), p.523-527 |
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| creator | Wheeler, E E Challacombe, D N |
| description | Enterochromaffin cells in the duodenal mucosa were stained by using a monoclonal antibody against serotonin immunoreactive sites and an indirect immunoperoxidase technique. A semi-automatic image analysing system showed increased numbers of these cells in patients with untreated coeliac disease compared with a control group. The number of serotonin positive granules in individual enterochromaffin cells also seemed to be increased in patients with coeliac disease, a finding which may be related to the pathogenesis of this disorder. |
| doi_str_mv | 10.1136/adc.59.6.523 |
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A semi-automatic image analysing system showed increased numbers of these cells in patients with untreated coeliac disease compared with a control group. The number of serotonin positive granules in individual enterochromaffin cells also seemed to be increased in patients with coeliac disease, a finding which may be related to the pathogenesis of this disorder.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.59.6.523</identifier><identifier>PMID: 6378103</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Adolescent ; Antibodies, Monoclonal - immunology ; Biological and medical sciences ; Celiac Disease - metabolism ; Celiac Disease - pathology ; Cell Count ; Child ; Child, Preschool ; Chromaffin System - pathology ; Duodenum - analysis ; Duodenum - pathology ; Enterochromaffin Cells - analysis ; Enterochromaffin Cells - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Glutens ; Humans ; Immunoenzyme Techniques ; Infant ; Intestinal Mucosa - analysis ; Intestinal Mucosa - pathology ; Male ; Medical sciences ; Other diseases. Semiology ; Serotonin - analysis ; Serotonin - immunology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><ispartof>Archives of disease in childhood, 1984-06, Vol.59 (6), p.523-527</ispartof><rights>1985 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Jun 1984</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4213-64f29074e426c9acdc4f9a7dba116493aa8640fa0e4c05ff51a1a798b0a99a803</citedby><cites>FETCH-LOGICAL-b4213-64f29074e426c9acdc4f9a7dba116493aa8640fa0e4c05ff51a1a798b0a99a803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1628750/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1628750/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8874965$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6378103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wheeler, E E</creatorcontrib><creatorcontrib>Challacombe, D N</creatorcontrib><title>Quantification of enterochromaffin cells with serotonin immunoreactivity in the duodenal mucosa in coeliac disease</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>Enterochromaffin cells in the duodenal mucosa were stained by using a monoclonal antibody against serotonin immunoreactive sites and an indirect immunoperoxidase technique. A semi-automatic image analysing system showed increased numbers of these cells in patients with untreated coeliac disease compared with a control group. The number of serotonin positive granules in individual enterochromaffin cells also seemed to be increased in patients with coeliac disease, a finding which may be related to the pathogenesis of this disorder.</description><subject>Adolescent</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Biological and medical sciences</subject><subject>Celiac Disease - metabolism</subject><subject>Celiac Disease - pathology</subject><subject>Cell Count</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromaffin System - pathology</subject><subject>Duodenum - analysis</subject><subject>Duodenum - pathology</subject><subject>Enterochromaffin Cells - analysis</subject><subject>Enterochromaffin Cells - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Glutens</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Infant</subject><subject>Intestinal Mucosa - analysis</subject><subject>Intestinal Mucosa - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Serotonin - analysis</subject><subject>Serotonin - immunology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kcuLFDEYxIMo6zh68yo0KOvFHpPudB4XwR0fKywrgg_wEr5OJ07G7mRN0qv735thhkE9eApU_SgqXyH0kOAVIS17DoNedXLFVl3T3kILQpmoG0zpbbTAGLe1FELcRfdS2mJMGiHaE3TCWi4IbhcofpjBZ2edhuyCr4KtjM8mBr2JYQJrna-0GcdU_XR5U6Xi5OCL6KZp9iEa0Nldu3xTFS1vTDXMYTAexmqadUiwk3UwowNdDS4ZSOY-umNhTObB4V2iT29ef1yf1xfv375bv7yoe9qQtmbUNhJzamjDtAQ9aGol8KEHQhiVLYBgFFvAhmrcWdsRIMCl6DFICQK3S_Rin3s195MZdPlXhFFdRTdBvFEBnPrb8W6jvoVrRVgjeLcLOD0ExPBjNimryaXdMcCbMCclCOkYKVWW6PE_4DbMsRwhKcKZ5JJIJgr1bE_pGFKKxh6rEKx2S6qypOqkYqosWfBHf9Y_wofpiv_k4EPSMNoIXrt0xITgVLKuYPUecymbX0cb4nfFeMs7dfl5rc67V1_OLpuvihf-6Z7vp-3_C_4GJWXFBQ</recordid><startdate>19840601</startdate><enddate>19840601</enddate><creator>Wheeler, E E</creator><creator>Challacombe, D N</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19840601</creationdate><title>Quantification of enterochromaffin cells with serotonin immunoreactivity in the duodenal mucosa in coeliac disease</title><author>Wheeler, E E ; Challacombe, D N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4213-64f29074e426c9acdc4f9a7dba116493aa8640fa0e4c05ff51a1a798b0a99a803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adolescent</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Biological and medical sciences</topic><topic>Celiac Disease - metabolism</topic><topic>Celiac Disease - pathology</topic><topic>Cell Count</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromaffin System - pathology</topic><topic>Duodenum - analysis</topic><topic>Duodenum - pathology</topic><topic>Enterochromaffin Cells - analysis</topic><topic>Enterochromaffin Cells - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Glutens</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Infant</topic><topic>Intestinal Mucosa - analysis</topic><topic>Intestinal Mucosa - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Serotonin - analysis</topic><topic>Serotonin - immunology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wheeler, E E</creatorcontrib><creatorcontrib>Challacombe, D N</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wheeler, E E</au><au>Challacombe, D N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantification of enterochromaffin cells with serotonin immunoreactivity in the duodenal mucosa in coeliac disease</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>1984-06-01</date><risdate>1984</risdate><volume>59</volume><issue>6</issue><spage>523</spage><epage>527</epage><pages>523-527</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>Enterochromaffin cells in the duodenal mucosa were stained by using a monoclonal antibody against serotonin immunoreactive sites and an indirect immunoperoxidase technique. A semi-automatic image analysing system showed increased numbers of these cells in patients with untreated coeliac disease compared with a control group. The number of serotonin positive granules in individual enterochromaffin cells also seemed to be increased in patients with coeliac disease, a finding which may be related to the pathogenesis of this disorder.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>6378103</pmid><doi>10.1136/adc.59.6.523</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of disease in childhood, 1984-06, Vol.59 (6), p.523-527 |
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| subjects | Adolescent Antibodies, Monoclonal - immunology Biological and medical sciences Celiac Disease - metabolism Celiac Disease - pathology Cell Count Child Child, Preschool Chromaffin System - pathology Duodenum - analysis Duodenum - pathology Enterochromaffin Cells - analysis Enterochromaffin Cells - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Glutens Humans Immunoenzyme Techniques Infant Intestinal Mucosa - analysis Intestinal Mucosa - pathology Male Medical sciences Other diseases. Semiology Serotonin - analysis Serotonin - immunology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Quantification of enterochromaffin cells with serotonin immunoreactivity in the duodenal mucosa in coeliac disease |
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