l-dopa impairs learning, but spares generalization, in Parkinson's disease

In this study we examined the effect of dopaminergic modulation on learning and memory. Parkinson's patients were tested ‘on’ versus ‘off’ dopaminergic medication, using a two-phase learning and transfer task. We found that dopaminergic medication was associated with impaired learning of an inc...

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Veröffentlicht in:	Neuropsychologia 2006-01, Vol.44 (5), p.774-784
Hauptverfasser:	Shohamy, Daphna, Myers, Catherine E., Geghman, Kindiya D., Sage, Jacob, Gluck, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Aged Analysis of Variance Antiparkinson Agents - adverse effects Basal ganglia Biological and medical sciences Case-Control Studies Cognition Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Discrimination (Psychology) - drug effects Dopamine Female Generalization (Psychology) - drug effects Humans Learning Learning - drug effects Learning Disorders - chemically induced Levodopa - adverse effects Male Medical sciences Memory Middle Aged Neurology Neuropsychological Tests Organic mental disorders. Neuropsychology Parkinson Disease - drug therapy Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry
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