Variation at the Rat Crhr1 Locus and Sensitivity to Relapse into Alcohol Seeking Induced by Environmental Stress

Alcoholism is a chronic relapsing disorder with substantial heritability. Uncovering gene-environment interactions underlying this disease process can aid identification of novel treatment targets. Here, we found a lowered threshold for stress-induced reinstatement of alcohol seeking in Marchigian-S...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-10, Vol.103 (41), p.15236-15241
Hauptverfasser:	Hansson, A. C., Cippitelli, A., Sommer, W. H., Fedeli, A., Björk, K., Soverchia, L., Terasmaa, A., Massi, M., Heilig, M., Ciccocioppo, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol drinking Alcoholic beverages Alcoholism Alcoholism - genetics Alcoholism - psychology Alcohols Animals Behavior, Animal - physiology Biological Sciences Fornix Gene expression Genetic loci Genetic Predisposition to Disease Genetic Variation Genotype Genotype & phenotype Hormones Male Medical genetics Phenotypes Rats Rats, Mutant Strains Rats, Wistar Receptors Receptors, Corticotropin-Releasing Hormone - biosynthesis Receptors, Corticotropin-Releasing Hormone - genetics Receptors, Corticotropin-Releasing Hormone - physiology Recurrence Relapse Rodents Stress, Physiological - genetics Stress, Physiological - psychology
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