The thyroid hormone receptor antagonizes CREB-mediated transcription

Combinatorial regulation of transcription involves binding of transcription factors to DNA as well as protein–protein interactions between them. In this paper, we demonstrate the existence of a mutual transcriptional antagonism between the thyroid hormone receptor (TR) and the cyclic AMP response el...

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Veröffentlicht in:	The EMBO journal 2003-06, Vol.22 (12), p.3102-3112
Hauptverfasser:	Méndez-Pertuz, Marinela, Sánchez-Pacheco, Aurora, Aranda, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line CREB CREB phosphorylation CREB-Binding Protein Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism EMBO09 EMBO37 Genes, Reporter Humans Hydroxamic Acids - metabolism Nuclear Proteins - metabolism Phosphorylation Pituitary Gland - cytology Pituitary Gland - metabolism Promoter Regions, Genetic Protein Synthesis Inhibitors - metabolism Receptors, Thyroid Hormone - genetics Receptors, Thyroid Hormone - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Response Elements Signal Transduction - physiology Thyroid thyroid hormone receptor Trans-Activators - metabolism Transcription, Genetic transcriptional repression Triiodothyronine - metabolism
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