Role of nitric oxide and superoxide in allergen‐induced airway hyperreactivity after the late asthmatic reaction in guinea‐pigs

In the present study, the roles of nitric oxide (NO) and superoxide anions (O2−) in allergen‐induced airway hyperreactivity (AHR) after the late asthmatic reaction (LAR) were investigated ex vivo, by examining the effects of the NO synthase inhibitor Nω‐nitro‐L‐arginine methyl ester (L‐NAME) and sup...

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Veröffentlicht in:	British journal of pharmacology 2001-08, Vol.133 (8), p.1235-1242
Hauptverfasser:	Boer, Jacob de, Meurs, Herman, Flendrig, Leonard, Koopal, Miranda, Zaagsma, Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	airway hyperreactivity Allergens - immunology Animals Asthma - chemically induced Asthma - immunology Asthma - metabolism Asthma - physiopathology Biological and medical sciences Bronchial Hyperreactivity - chemically induced Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - metabolism Bronchial Hyperreactivity - physiopathology Bronchoconstrictor Agents - pharmacology Chronic obstructive pulmonary disease, asthma Guinea Pigs guinea‐pig Histamine - pharmacology late asthmatic reaction Medical sciences methacholine Methacholine Chloride - pharmacology NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - metabolism Ovalbumin - immunology Perfusion peroxynitrite Pneumology Respiration - drug effects superoxide anion Superoxide Dismutase - pharmacology Superoxides - metabolism Trachea - drug effects Trachea - metabolism Trachea - physiopathology tracheal perfusion
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