Dependence of Cardiac 11C-meta-Hydroxyephedrine Retention on Norepinephrine Transporter Density

The norepinephrine analog (11)C-meta-hydroxyephedrine (HED) is used with PET to map the regional distribution of cardiac sympathetic neurons. HED is rapidly transported into sympathetic neurons by the norepinephrine transporter (NET) and stored in vesicles. Although much is known about the neuronal...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2006-09, Vol.47 (9), p.1490-1496
Hauptverfasser:	Raffel, David M, Chen, Wei, Sherman, Phillip S, Gildersleeve, David L, Jung, Yong-Woon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon Radioisotopes Ephedrine - analogs & derivatives Ephedrine - pharmacokinetics Heart - diagnostic imaging Heart - innervation Male Metabolic Clearance Rate Myocardium - metabolism Norepinephrine Plasma Membrane Transport Proteins - metabolism Radionuclide Imaging Radiopharmaceuticals - pharmacokinetics Rats Rats, Sprague-Dawley Sympathetic Nervous System - diagnostic imaging Sympathetic Nervous System - metabolism Tissue Distribution
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