The Mannose-Binding Lectin-Pathway Is Involved in Complement Activation in the Course of Renal Ischemia-Reperfusion Injury

Ischemia-reperfusion (I/R) is an important cause of acute renal failure (ARF). The complement system appears to be essentially involved in I/R injury. However, via which pathway the complement system is activated and in particular whether the mannose-binding lectin (MBL)-pathway is activated is uncl...

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Veröffentlicht in:	The American journal of pathology 2004-11, Vol.165 (5), p.1677-1688
Hauptverfasser:	de Vries, Bart, Walter, Sarah J., Peutz-Kootstra, Carine J., Wolfs, Tim G.A.M., van Heurn, L.W. Ernest, Buurman, Wim A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Biological and medical sciences Biopsy Complement Activation Enzyme-Linked Immunosorbent Assay Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Kidney - metabolism Kidney - pathology Lectins Liver - metabolism Lung - metabolism Male Mannose - chemistry Mannose-Binding Lectin - chemistry Medical sciences Mice Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Neutrophils - metabolism Original Research Paper Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Peroxidase - metabolism Protein Binding Renovascular diseases Reperfusion Injury - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Time Factors
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