The Novel Marker, DOG1, Is Expressed Ubiquitously in Gastrointestinal Stromal Tumors Irrespective of KIT or PDGFRA Mutation Status

We recently characterized gene expression patterns in gastrointestinal stromal tumors (GISTs) using cDNA microarrays, and found that the gene FLJ10261 ( DOG1 , discovered on GIST-1), encoding a hypothetical protein, was specifically expressed in GISTs. The immunoreactivity of a rabbit antiserum to s...

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Veröffentlicht in:	The American journal of pathology 2004-07, Vol.165 (1), p.107-113
Hauptverfasser:	West, Robert B., Corless, Christopher L., Chen, Xin, Rubin, Brian P., Subramanian, Subbaya, Montgomery, Kelli, Zhu, Shirley, Ball, Catherine A., Nielsen, Torsten O., Patel, Rajiv, Goldblum, John R., Brown, Patrick O., Heinrich, Michael C., van de Rijn, Matt
Format:	Artikel
Sprache:	eng
Schlagworte:	Anoctamin-1 Biological and medical sciences Biomarkers - analysis Chloride Channels Gastrointestinal Neoplasms - metabolism Gastrointestinal Neoplasms - pathology Humans Immunohistochemistry In Situ Hybridization Investigative techniques, diagnostic techniques (general aspects) Medical sciences Membrane Proteins - analysis Mutation Neoplasm Proteins - analysis Oligonucleotide Array Sequence Analysis Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phosphoric Monoester Hydrolases Proto-Oncogene Proteins c-kit - genetics Receptor, Platelet-Derived Growth Factor alpha - genetics Regular Saccharomyces cerevisiae Proteins Stromal Cells - metabolism Stromal Cells - pathology
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