Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

1 The reversible fatty acid amide hydrolase (FAAH) inhibitor OL135 reverses mechanical allodynia in the spinal nerve ligation (SNL) and mild thermal injury (MTI) models in the rat. The purpose of this study was to investigate the role of the cannabinoid and opioid systems in mediating this analgesic...

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Veröffentlicht in:	British journal of pharmacology 2006-05, Vol.148 (1), p.102-113
Hauptverfasser:	Chang, Leon, Luo, Lin, Palmer, James A, Sutton, Steven, Wilson, Sandy J, Barbier, Ann J, Breitenbucher, James Guy, Chaplan, Sandra R, Webb, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - antagonists & inhibitors Amidohydrolases - genetics Amidohydrolases - metabolism analgesia Analgesics - pharmacology Animals Arachidonic Acids - metabolism Biological and medical sciences Brain - drug effects Brain - enzymology cannabinoid receptor Dose-Response Relationship, Drug endocannabinoid Endocannabinoids Enzyme Inhibitors - pharmacology FAAH fatty acid amide fatty acid amide hydrolase Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Models, Animal naloxone Naloxone - pharmacology Narcotic Antagonists - pharmacology pain Pain - enzymology Pain - prevention & control Pain Measurement Pharmacology. Drug treatments Polyunsaturated Alkamides - metabolism Pyridines - pharmacology Rats Rats, Sprague-Dawley Spinal Cord - drug effects Spinal Cord - enzymology
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