Genetic Epidemiology of Intracerebral Hemorrhage
We have previously reported that family history of intracerebral hemorrhage (ICH) was associated with both lobar and nonlobar ICH. We sought to further examine this finding by analyzing differences by age and by apolipoprotein E (Apo E) genotype. All cases of hemorrhagic stroke in the greater Cincin...
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| Veröffentlicht in: | Journal of stroke and cerebrovascular diseases 2005-11, Vol.14 (6), p.239-243 |
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| creator | Woo, Daniel Sekar, Padmini Chakraborty, Ranajit Haverbusch, Mary A. Flaherty, Matthew L. Kissela, Brett M. Kleindorfer, Dawn Schneider, Alexander Khoury, Jane Sauerbeck, Laura R. Deka, Ranjan Broderick, Joseph P. |
| description | We have previously reported that family history of intracerebral hemorrhage (ICH) was associated with both lobar and nonlobar ICH. We sought to further examine this finding by analyzing differences by age and by apolipoprotein E (Apo E) genotype. All cases of hemorrhagic stroke in the greater Cincinnati area were identified through retrospective screening, and a subset was invited to undergo a direct interview and genetic testing. Interviewed subjects were matched to 2 controls by age, race, and sex. Conditional stepwise logistic regression modeling was used to determine whether having a first-degree relative with an ICH (FHICH) was an independent risk factor for ICH. Between May 1997 and December 2002, we recruited 333 cases of ICH. FHICH was found to be an independent risk factor for both lobar ICH (odds ratio [OR] = 3.9;
P = .04) and nonlobar ICH (OR ratio = 5.4;
P = .01) after controlling for the presence of numerous variables. Among nonlobar ICH cases, the risk appeared to be predominately in those age |
| doi_str_mv | 10.1016/j.jstrokecerebrovasdis.2005.08.002 |
| format | Article |
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P = .04) and nonlobar ICH (OR ratio = 5.4;
P = .01) after controlling for the presence of numerous variables. Among nonlobar ICH cases, the risk appeared to be predominately in those age <70 years. The presence of Apo E4 was associated with lobar ICH at age ≥70 years but not at age <70 years. Family history of ICH appears to be a significant risk factor for nonlobar ICH at age <70 years. The presence of Apo E4 appears to be a risk factor for lobar ICH at age ≥70 years but not at age <70 years. Family history of ICH is a risk factor for lobar ICH after controlling for the presence of Apo E4.</description><identifier>ISSN: 1052-3057</identifier><identifier>EISSN: 1532-8511</identifier><identifier>DOI: 10.1016/j.jstrokecerebrovasdis.2005.08.002</identifier><identifier>PMID: 16557295</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>apolipoprotein E ; epidemiology ; Genetics ; hypertension ; intracerebral hemorrhage ; lobar ; risk factors</subject><ispartof>Journal of stroke and cerebrovascular diseases, 2005-11, Vol.14 (6), p.239-243</ispartof><rights>2005 National Stroke Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4612-7a3191e22501c34ba354320c3b01451991ddee8094f35c03726082c9159558da3</citedby><cites>FETCH-LOGICAL-c4612-7a3191e22501c34ba354320c3b01451991ddee8094f35c03726082c9159558da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2005.08.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16557295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woo, Daniel</creatorcontrib><creatorcontrib>Sekar, Padmini</creatorcontrib><creatorcontrib>Chakraborty, Ranajit</creatorcontrib><creatorcontrib>Haverbusch, Mary A.</creatorcontrib><creatorcontrib>Flaherty, Matthew L.</creatorcontrib><creatorcontrib>Kissela, Brett M.</creatorcontrib><creatorcontrib>Kleindorfer, Dawn</creatorcontrib><creatorcontrib>Schneider, Alexander</creatorcontrib><creatorcontrib>Khoury, Jane</creatorcontrib><creatorcontrib>Sauerbeck, Laura R.</creatorcontrib><creatorcontrib>Deka, Ranjan</creatorcontrib><creatorcontrib>Broderick, Joseph P.</creatorcontrib><title>Genetic Epidemiology of Intracerebral Hemorrhage</title><title>Journal of stroke and cerebrovascular diseases</title><addtitle>J Stroke Cerebrovasc Dis</addtitle><description>We have previously reported that family history of intracerebral hemorrhage (ICH) was associated with both lobar and nonlobar ICH. We sought to further examine this finding by analyzing differences by age and by apolipoprotein E (Apo E) genotype. All cases of hemorrhagic stroke in the greater Cincinnati area were identified through retrospective screening, and a subset was invited to undergo a direct interview and genetic testing. Interviewed subjects were matched to 2 controls by age, race, and sex. Conditional stepwise logistic regression modeling was used to determine whether having a first-degree relative with an ICH (FHICH) was an independent risk factor for ICH. Between May 1997 and December 2002, we recruited 333 cases of ICH. FHICH was found to be an independent risk factor for both lobar ICH (odds ratio [OR] = 3.9;
P = .04) and nonlobar ICH (OR ratio = 5.4;
P = .01) after controlling for the presence of numerous variables. Among nonlobar ICH cases, the risk appeared to be predominately in those age <70 years. The presence of Apo E4 was associated with lobar ICH at age ≥70 years but not at age <70 years. Family history of ICH appears to be a significant risk factor for nonlobar ICH at age <70 years. The presence of Apo E4 appears to be a risk factor for lobar ICH at age ≥70 years but not at age <70 years. Family history of ICH is a risk factor for lobar ICH after controlling for the presence of Apo E4.</description><subject>apolipoprotein E</subject><subject>epidemiology</subject><subject>Genetics</subject><subject>hypertension</subject><subject>intracerebral hemorrhage</subject><subject>lobar</subject><subject>risk factors</subject><issn>1052-3057</issn><issn>1532-8511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqVkM1KK0EQhRtR_H8FycqFMHOruqfmZyNo8KoQcKPrptNTiR1npmP3JODbOyHhqnA3rqqgDt8pPiGuEFIEzP8s0kXsg39jy4Gnwa9NrF1MJQClUKYAck8cIymZlIS4P-xAMlFAxZE4iXEBgEglHYojzIkKWdGxgHvuuHd2dLd0NbfON37-MfKz0WPXB7MtMs3ogVsfwquZ85k4mJkm8vlunoqXv3fP44dk8nT_OL6ZJDbLUSaFUVghS0mAVmVToyhTEqyaAmaEVYV1zVxClc0UWVCFzKGUtkKqiMraqFNxveUuV9OWa8ubfxq9DK414UN74_TPS-de9dyvNeZIBWYD4HIHCP59xbHXrYuWm8Z07FdR50WOVUHFELzdBm3wMQae_StB0BvxeqH_J15vxGso9SB-gFx8f_cLsTM9BCbbAA_S1o6DjtZxZ7l2gW2va-9-0_cJFNyiVw</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Woo, Daniel</creator><creator>Sekar, Padmini</creator><creator>Chakraborty, Ranajit</creator><creator>Haverbusch, Mary A.</creator><creator>Flaherty, Matthew L.</creator><creator>Kissela, Brett M.</creator><creator>Kleindorfer, Dawn</creator><creator>Schneider, Alexander</creator><creator>Khoury, Jane</creator><creator>Sauerbeck, Laura R.</creator><creator>Deka, Ranjan</creator><creator>Broderick, Joseph P.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200511</creationdate><title>Genetic Epidemiology of Intracerebral Hemorrhage</title><author>Woo, Daniel ; Sekar, Padmini ; Chakraborty, Ranajit ; Haverbusch, Mary A. ; Flaherty, Matthew L. ; Kissela, Brett M. ; Kleindorfer, Dawn ; Schneider, Alexander ; Khoury, Jane ; Sauerbeck, Laura R. ; Deka, Ranjan ; Broderick, Joseph P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4612-7a3191e22501c34ba354320c3b01451991ddee8094f35c03726082c9159558da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>apolipoprotein E</topic><topic>epidemiology</topic><topic>Genetics</topic><topic>hypertension</topic><topic>intracerebral hemorrhage</topic><topic>lobar</topic><topic>risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woo, Daniel</creatorcontrib><creatorcontrib>Sekar, Padmini</creatorcontrib><creatorcontrib>Chakraborty, Ranajit</creatorcontrib><creatorcontrib>Haverbusch, Mary A.</creatorcontrib><creatorcontrib>Flaherty, Matthew L.</creatorcontrib><creatorcontrib>Kissela, Brett M.</creatorcontrib><creatorcontrib>Kleindorfer, Dawn</creatorcontrib><creatorcontrib>Schneider, Alexander</creatorcontrib><creatorcontrib>Khoury, Jane</creatorcontrib><creatorcontrib>Sauerbeck, Laura R.</creatorcontrib><creatorcontrib>Deka, Ranjan</creatorcontrib><creatorcontrib>Broderick, Joseph P.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of stroke and cerebrovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woo, Daniel</au><au>Sekar, Padmini</au><au>Chakraborty, Ranajit</au><au>Haverbusch, Mary A.</au><au>Flaherty, Matthew L.</au><au>Kissela, Brett M.</au><au>Kleindorfer, Dawn</au><au>Schneider, Alexander</au><au>Khoury, Jane</au><au>Sauerbeck, Laura R.</au><au>Deka, Ranjan</au><au>Broderick, Joseph P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Epidemiology of Intracerebral Hemorrhage</atitle><jtitle>Journal of stroke and cerebrovascular diseases</jtitle><addtitle>J Stroke Cerebrovasc Dis</addtitle><date>2005-11</date><risdate>2005</risdate><volume>14</volume><issue>6</issue><spage>239</spage><epage>243</epage><pages>239-243</pages><issn>1052-3057</issn><eissn>1532-8511</eissn><abstract>We have previously reported that family history of intracerebral hemorrhage (ICH) was associated with both lobar and nonlobar ICH. We sought to further examine this finding by analyzing differences by age and by apolipoprotein E (Apo E) genotype. All cases of hemorrhagic stroke in the greater Cincinnati area were identified through retrospective screening, and a subset was invited to undergo a direct interview and genetic testing. Interviewed subjects were matched to 2 controls by age, race, and sex. Conditional stepwise logistic regression modeling was used to determine whether having a first-degree relative with an ICH (FHICH) was an independent risk factor for ICH. Between May 1997 and December 2002, we recruited 333 cases of ICH. FHICH was found to be an independent risk factor for both lobar ICH (odds ratio [OR] = 3.9;
P = .04) and nonlobar ICH (OR ratio = 5.4;
P = .01) after controlling for the presence of numerous variables. Among nonlobar ICH cases, the risk appeared to be predominately in those age <70 years. The presence of Apo E4 was associated with lobar ICH at age ≥70 years but not at age <70 years. Family history of ICH appears to be a significant risk factor for nonlobar ICH at age <70 years. The presence of Apo E4 appears to be a risk factor for lobar ICH at age ≥70 years but not at age <70 years. Family history of ICH is a risk factor for lobar ICH after controlling for the presence of Apo E4.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16557295</pmid><doi>10.1016/j.jstrokecerebrovasdis.2005.08.002</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | apolipoprotein E epidemiology Genetics hypertension intracerebral hemorrhage lobar risk factors |
| title | Genetic Epidemiology of Intracerebral Hemorrhage |
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