Degree and Duration of Reversal by Naloxone of Effects of Morphine in Conscious Subjects

The effects of intravenous naloxone on several of the actions of intravenous morphine (mean dose 30 mg/70 kg) were studied in six volunteer subjects. Naloxone produced a well defined reversal of the respiratory depression, analgesia, and miotic and subjective effects of the morphine. The agonist act...

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Veröffentlicht in:	BMJ 1974-06, Vol.2 (5919), p.589-591
Hauptverfasser:	Evans, J. M., Hogg, M. I. J., Lunn, J. N., Rosen, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Analgesia Arousal - drug effects Blood Pressure - drug effects Carbon Dioxide Catheterization Constriction Depressants Dosage Humans Intravenous injections Male Morphine Morphine - antagonists & inhibitors Naloxone - pharmacology Narcotics Nausea Pain Pain sensitivity Papers and Originals Pupil - drug effects Pupil size Respiration - drug effects Respiratory insufficiency
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