Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum

HC toxin, the host-selective toxin of the maize pathogen Cochliobolus carbonum, inhibited maize histone deacetylase (HD) at 2 micromolar. Chlamydocin, a related cyclic tetrapeptide, also inhibited HD activity. The toxins did not affect histone acetyltransferases. After partial purification of histon...

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Veröffentlicht in:	The Plant cell 1995-11, Vol.7 (11), p.1941-1950
Hauptverfasser:	Brosch, Gerald, Ransom, Richard, Lechner, Thomas, Walton, Jonathan D., Loidl, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetyltransferases - metabolism actividad enzimatica activite enzymatique Animals Ascomycota Chickens Chromatin cochliobolus carbonum Corn embriones vegetales embryon vegetal Embryos enzyme inhibitors Enzyme Inhibitors - pharmacology Enzymes enzymic activity Erythrocytes - enzymology Gene expression Genotypes Helminthosporium hidrolasas histonas histone Histone Acetyltransferases Histone Deacetylase Inhibitors Histone Deacetylases - blood Histone Deacetylases - isolation & purification Histones Histones - isolation & purification Histones - metabolism hydrolase hydrolases inhibicion inhibidores de enzimas inhibiteur d' enzyme inhibition Kinetics micotoxinas mycotoxine mycotoxins Peptides, Cyclic - pharmacology Physarum - enzymology plant embryos Saccharomyces cerevisiae Proteins Toxins zea mays Zea mays - enzymology
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