Evidence for Circulating Immune Complexes in Thyroid Disease

Anti-complementary activity was detected in the sera of 23 (59%) out of 39 patients with Hashimoto thyroiditis; in 10 (29%) out of 34 patients with primary hypothyroidism; in six (17%) out of 36 patients with thyrotoxicosis; and in only six (8%) out of 78 control subjects. Fractionation of Hashimoto...

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Veröffentlicht in:	BMJ 1974-04, Vol.2 (5909), p.30-31
Hauptverfasser:	Calder, Elizabeth A., Penhale, W. J., Barnes, E. W., Irvine, W. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Anti-Idiotypic - analysis Antigen antibody complex Binding Sites, Antibody Chromatography, Gel Complement Inactivator Proteins Elution Guinea Pigs - immunology Hashimoto disease Humans Hyperthyroidism - immunology Hypothyroidism Hypothyroidism - immunology Immune Adherence Reaction Immunoglobulin G - analysis Immunology Lymphocytes Molecular Weight Papers and Originals Preliminary Communications Sheep - immunology Thyroid diseases Thyroid Diseases - immunology Thyroiditis Thyroiditis, Autoimmune - immunology Thyrotoxicosis
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Zusammenfassung:	Anti-complementary activity was detected in the sera of 23 (59%) out of 39 patients with Hashimoto thyroiditis; in 10 (29%) out of 34 patients with primary hypothyroidism; in six (17%) out of 36 patients with thyrotoxicosis; and in only six (8%) out of 78 control subjects. Fractionation of Hashimoto sera by Sephadex G-200 chromatography showed that the anti-complementary activity was founding fractions of larger molecular size than monomeric IgG, being localized predominantly in the ascending limb of the second elution peak, suggesting that it was in the form of small immune complexes.
ISSN:	0007-1447 0959-8138 1468-5833
DOI:	10.1136/bmj.2.5909.30