Conformational transitions induced in heparin octasaccharides by binding with antithrombin III

The present study deals with the conformation in solution of two heparin octasaccharides containing the pentasaccharide sequence GlcN(NAc,6S)-GlcA-GlcN(NS,3,6S)-IdoA(2S)-GlcN(NS,6S) [AGA*IA; where GlcN(NAc,6S) is N-acetylated, 6-O-sulfated alpha-D-glucosamine, GlcN(NS,3,6S) is N,3,6-O-trisulfated al...

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Veröffentlicht in:	Biochemical journal 2006-10, Vol.399 (2), p.191-198
Hauptverfasser:	Guerrini, Marco, Guglieri, Sara, Beccati, Daniela, Torri, Giangiacomo, Viskov, Christian, Mourier, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Antithrombin III - analysis Antithrombin III - chemistry Antithrombin III - metabolism Carbohydrate Conformation Heparin - analysis Heparin - chemistry Heparin - metabolism Humans Iduronic Acid - chemistry Models, Molecular Nuclear Magnetic Resonance, Biomolecular Oligosaccharides - analysis Oligosaccharides - chemistry Oligosaccharides - metabolism Protein Binding
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