Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis
Chromosomes were studied on diagnostic bone-marrow samples from 39 children with acute lymphoblastic leukaemia (ALL). The patients were classified, according to the chromosomal characteristics of the major proportion of their leukaemia cells, into five categories; hyperdiploid, pseudodiploid, diploi...
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| Veröffentlicht in: | BMJ 1978-12, Vol.2 (6151), p.1529-1530 |
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| creator | Secker-Walker, L M Lawler, S D Hardisty, R M |
| description | Chromosomes were studied on diagnostic bone-marrow samples from 39 children with acute lymphoblastic leukaemia (ALL). The patients were classified, according to the chromosomal characteristics of the major proportion of their leukaemia cells, into five categories; hyperdiploid, pseudodiploid, diploid, hypodiploid, and mixed. Patients in the hyperdiploid category had significantly longer first remissions than those in all other categories, and those in the pseudodiploid category had the shortest. Neither the absence of any normal cells nor the presence of detectable clones appeared to be an adverse feature. We suggest that the proportion of hyperdiploid cells, determined by conventional chromosomal staining techniques, may be used as an additional prognostic feature in childhood ALL. |
| doi_str_mv | 10.1136/bmj.2.6151.1529 |
| format | Article |
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The patients were classified, according to the chromosomal characteristics of the major proportion of their leukaemia cells, into five categories; hyperdiploid, pseudodiploid, diploid, hypodiploid, and mixed. Patients in the hyperdiploid category had significantly longer first remissions than those in all other categories, and those in the pseudodiploid category had the shortest. Neither the absence of any normal cells nor the presence of detectable clones appeared to be an adverse feature. We suggest that the proportion of hyperdiploid cells, determined by conventional chromosomal staining techniques, may be used as an additional prognostic feature in childhood ALL.</description><identifier>ISSN: 0007-1447</identifier><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>DOI: 10.1136/bmj.2.6151.1529</identifier><identifier>PMID: 281981</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Adolescent ; Bone Marrow - ultrastructure ; Child ; Child, Preschool ; Chromosome Aberrations ; Chromosomes ; Cytogenetics ; Diploidy ; Disease remission ; Female ; Humans ; Infant ; Leukemia ; Leukemia, Lymphoid - genetics ; Lymphocytic leukemia ; Male ; Mediastinal diseases ; Medical genetics ; Ploidies ; Prognosis ; Remission, Spontaneous</subject><ispartof>BMJ, 1978-12, Vol.2 (6151), p.1529-1530</ispartof><rights>Copyright 1978 British Medical Journal</rights><rights>Copyright BMJ Publishing Group LTD Dec 2, 1978</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b510t-f3d4a34d0a99ced2d23179bd6489aca3dad37834a02917bfd7a9b3c6211ffea3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25430160$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25430160$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/281981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Secker-Walker, L M</creatorcontrib><creatorcontrib>Lawler, S D</creatorcontrib><creatorcontrib>Hardisty, R M</creatorcontrib><title>Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis</title><title>BMJ</title><addtitle>Br Med J</addtitle><description>Chromosomes were studied on diagnostic bone-marrow samples from 39 children with acute lymphoblastic leukaemia (ALL). The patients were classified, according to the chromosomal characteristics of the major proportion of their leukaemia cells, into five categories; hyperdiploid, pseudodiploid, diploid, hypodiploid, and mixed. Patients in the hyperdiploid category had significantly longer first remissions than those in all other categories, and those in the pseudodiploid category had the shortest. Neither the absence of any normal cells nor the presence of detectable clones appeared to be an adverse feature. We suggest that the proportion of hyperdiploid cells, determined by conventional chromosomal staining techniques, may be used as an additional prognostic feature in childhood ALL.</description><subject>Adolescent</subject><subject>Bone Marrow - ultrastructure</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes</subject><subject>Cytogenetics</subject><subject>Diploidy</subject><subject>Disease remission</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Leukemia</subject><subject>Leukemia, Lymphoid - genetics</subject><subject>Lymphocytic leukemia</subject><subject>Male</subject><subject>Mediastinal diseases</subject><subject>Medical genetics</subject><subject>Ploidies</subject><subject>Prognosis</subject><subject>Remission, Spontaneous</subject><issn>0007-1447</issn><issn>0959-8138</issn><issn>1468-5833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtr3DAUhUXpa5hm3U0LhkIXBU_0smRtCmVI2sIwbSB0V8S1Jc9oYlsTyS7Jv69ch-lj05UQ37mHc-9B6CXBK0KYOK-6w4quBCnIihRUPUILwkWZFyVjj9ECYyxzwrl8js5iPKQvZbJUgj9DT2lJVEkW6PvX4He9j4OrM9cdW1fD4HwfM99k9T74zkffQZs1rjeu38XM9RnU42Cz9r477n3Vwq_Z1o43YDsHGQyZcTB5uvgCPWmgjfbs4V2i68uL6_WnfPPl4-f1h01eFQQPecMMB8YNBqVqa6ihjEhVGcFLBTUwAyYFZxwwVURWjZGgKlYLSkjTWGBL9H62PY5VZ01t-yFAq4_BdRDutQen_ya92-ud_6GJwKUseDJ4-2AQ_O1o46A7F2vbttBbP0YtOS15gVUSvvlHePBj6NNumkgpiBIi3X6JzmdVHXyMwTanKATrqTiditNUT8Xpqbg08erPDU76uaaEX8_4EAcfftMUHacdEs9n7uJg704cwo0WkslCb7-t9RUXl1fbzVZvkv7drJ9y_C_bT720vMg</recordid><startdate>19781202</startdate><enddate>19781202</enddate><creator>Secker-Walker, L M</creator><creator>Lawler, S D</creator><creator>Hardisty, R M</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19781202</creationdate><title>Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis</title><author>Secker-Walker, L M ; Lawler, S D ; Hardisty, R M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b510t-f3d4a34d0a99ced2d23179bd6489aca3dad37834a02917bfd7a9b3c6211ffea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adolescent</topic><topic>Bone Marrow - ultrastructure</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes</topic><topic>Cytogenetics</topic><topic>Diploidy</topic><topic>Disease remission</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Leukemia</topic><topic>Leukemia, Lymphoid - genetics</topic><topic>Lymphocytic leukemia</topic><topic>Male</topic><topic>Mediastinal diseases</topic><topic>Medical genetics</topic><topic>Ploidies</topic><topic>Prognosis</topic><topic>Remission, Spontaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Secker-Walker, L M</creatorcontrib><creatorcontrib>Lawler, S D</creatorcontrib><creatorcontrib>Hardisty, R M</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Secker-Walker, L M</au><au>Lawler, S D</au><au>Hardisty, R M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis</atitle><jtitle>BMJ</jtitle><addtitle>Br Med J</addtitle><date>1978-12-02</date><risdate>1978</risdate><volume>2</volume><issue>6151</issue><spage>1529</spage><epage>1530</epage><pages>1529-1530</pages><issn>0007-1447</issn><issn>0959-8138</issn><eissn>1468-5833</eissn><abstract>Chromosomes were studied on diagnostic bone-marrow samples from 39 children with acute lymphoblastic leukaemia (ALL). The patients were classified, according to the chromosomal characteristics of the major proportion of their leukaemia cells, into five categories; hyperdiploid, pseudodiploid, diploid, hypodiploid, and mixed. Patients in the hyperdiploid category had significantly longer first remissions than those in all other categories, and those in the pseudodiploid category had the shortest. Neither the absence of any normal cells nor the presence of detectable clones appeared to be an adverse feature. We suggest that the proportion of hyperdiploid cells, determined by conventional chromosomal staining techniques, may be used as an additional prognostic feature in childhood ALL.</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>281981</pmid><doi>10.1136/bmj.2.6151.1529</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Bone Marrow - ultrastructure Child Child, Preschool Chromosome Aberrations Chromosomes Cytogenetics Diploidy Disease remission Female Humans Infant Leukemia Leukemia, Lymphoid - genetics Lymphocytic leukemia Male Mediastinal diseases Medical genetics Ploidies Prognosis Remission, Spontaneous |
| title | Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis |
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