Pathogenic Role of B Cells in Anti-CD40-Induced Necroinflammatory Liver Disease

Activated B cells function in antibody production and antigen presentation, but whether they perform any pathophysiological functions at sites of inflammation is not fully understood. Here, we report that intravenous injection of an agonistic anti-CD40 monoclonal antibody (αCD40) causes a biphasic i...

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Veröffentlicht in:	The American journal of pathology 2006-03, Vol.168 (3), p.786-795
Hauptverfasser:	Kimura, Kiminori, Moriwaki, Hisataka, Nagaki, Masahito, Saio, Masanao, Nakamoto, Yasunari, Naito, Makoto, Kuwata, Kazuo, Chisari, Francis V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology B-Lymphocytes - drug effects B-Lymphocytes - immunology CD40 Antigens - drug effects CD40 Antigens - immunology Hepatitis - immunology Hepatitis - metabolism Hepatitis - pathology Interferon-gamma - metabolism Liver - drug effects Liver - immunology Liver - pathology Lymphocyte Activation Mice Mice, SCID Necrosis Original Research Paper Tumor Necrosis Factor-alpha - metabolism
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