Autophagic Cardiomyocyte Death in Cardiomyopathic Hamsters and Its Prevention by Granulocyte Colony-Stimulating Factor

In UM-X7.1 hamster model of human dilated cardiomyopathy, heart failure progressively develops and causes 50% mortality by 30 weeks of age. Through ultrastructural analysis, we found that many cardiomyocytes of this model contain typical autophagic vacuoles including degraded mitochondria, glycogen...

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Veröffentlicht in:	The American journal of pathology 2006-02, Vol.168 (2), p.386-397
Hauptverfasser:	Miyata, Shusaku, Takemura, Genzou, Kawase, Yukinori, Li, Yiwen, Okada, Hideshi, Maruyama, Rumi, Ushikoshi, Hiroaki, Esaki, Masayasu, Kanamori, Hiromitsu, Li, Longhu, Misao, Yu, Tezuka, Asaki, Toyo-Oka, Teruhiko, Minatoguchi, Shinya, Fujiwara, Takako, Fujiwara, Hisayoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autophagy Biological and medical sciences Cardiomyopathy, Dilated - metabolism Cardiomyopathy, Dilated - prevention & control Cathepsin D - metabolism Cricetinae Fibrosis - metabolism Fibrosis - prevention & control Granulocyte Colony-Stimulating Factor - therapeutic use Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Mesocricetus Mitochondria - pathology Myelin Sheath Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Original Research Paper Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proto-Oncogene Proteins c-akt - metabolism rab GTP-Binding Proteins - metabolism Recombinant Proteins STAT3 Transcription Factor - metabolism Survival Rate Tumor Necrosis Factor-alpha - metabolism Ubiquitin - metabolism Vacuoles
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