A Prostacyclin Analog Prevents Radiocontrast Nephropathy via Phosphorylation of Cyclic AMP Response Element Binding Protein

We reported previously that radiocontrast medium induces caspase-dependent apoptosis and that cAMP analogs inhibit cell injury in cultured renal tubular cells. In the present study, cellular me-chanisms underlying the protective effects of cAMP were determined. Ioversol, a radiocontrast medium, caus...

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Veröffentlicht in:	The American journal of pathology 2005-05, Vol.166 (5), p.1333-1342
Hauptverfasser:	Yano, Takahisa, Itoh, Yoshinori, Kubota, Toshio, Sendo, Toshiaki, Koyama, Tatsuya, Fujita, Takuya, Saeki, Kumiko, Yuo, Akira, Oishi, Ryozo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Bucladesine - pharmacology Caspases - metabolism Cell Survival - drug effects Contrast Media Cyclic AMP Response Element-Binding Protein - metabolism Enzyme Activation - drug effects Epoprostenol - analogs & derivatives Epoprostenol - pharmacology Investigative techniques, diagnostic techniques (general aspects) Kidney - metabolism Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - pathology Kidney Diseases - prevention & control LLC-PK1 Cells Medical sciences Mice Original Research Paper Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Phosphotransferases - metabolism Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-bcl-2 - metabolism Swine Triiodobenzoic Acids
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